Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid. (1986)
In order to survive in an oxygen environment, aerobic organisms have developed numerous mechanisms to protect against oxygen radicals and singlet oxygen. One such mechanism, which appears to have attained particular significance during primate evolution, is the direct scavenging of oxygen radicals, singlet oxygen, oxo-haem oxidants and hydroperoxyl radicals by uric acid. In the present paper we demonstrate that another important 'antioxidant' property of uric acid is the ability to form stable co-ordination complexes with iron ions.
post linking low zinc with various issues in ms including associated low uric acid and links to iron chelation...
hmm that link does not jump to the right post.. here's the content
hey there hub - nice addition to the file

i don't think you've duplicated anything
Quote:
JimmyLegs - This might have already been posted, but it appears that there might be a link between venous insufficiency and low zinc levels. Here's an intruiging excerpt from the following paper:
http://www.springerlink.com/content/n207g5g3k2414n7w/Quote: Chronic venous insufficiency... Depressed levels of zinc have been noted in patients with CVI and venous ulcer
i went through the earlier pages of this thread, to sort of get the zinc info in one place:
on CCSVI page 3..
Quote:
http://www.rowett.ac.uk/newsletter/Resources/nl10_articles/article4.pdf
...vascular disease is accelerated in marginal zinc deficiency and investigates a mechanistic basis for this influence, possibly involving vascular smooth muscle structural proteins...
http://grande.nal.usda.gov/ibids/index. ... row=361901Our data indicate that zinc is vital to vascular endothelial cell integrity, possibly by regulating signaling events to inhibit apoptotic cell death.
couple more from CCSVI page 7..
Quote:
http://www.jacn.org/cgi/content/abstract/27/5/577
Zinc Deficiency Induces Vascular Pro-Inflammatory Parameters
http://www.ebmonline.org/cgi/content/full/223/2/175Zinc Deficiency Exacerbates Loss in Blood-Brain Barrier Integrity Induced by Hyperoxia Measured by Dynamic MRI
and CCSVI page 10...
Quote:
Williams and colleagues compared the nutritional status of a group of 10 women with multiple sclerosis and pressure ulcers with 10 women free from any chronic wound... serum zinc levels were considerably less than normal ranges, suggesting a more significant deficiency.
CCSVI page 16...
Quote:
Zinc Deficiency Induces Vascular Pro-Inflammatory Parameters Associated with NF-{kappa}B and PPAR Signaling
In the current study we hypothesized that vascular dysfunction and associated inflammatory events are activated during a zinc deficient state.
Zinc deficiency increased oxidative stress and NF-{kappa}B DNA binding activity... as well as monocyte adhesion in cultured endothelial cells.
... rosiglitazone induced inflammatory genes (e.g., MCP-1) only during zinc deficiency... adequate zinc was required for rosiglitazone to down-regulate pro-inflammatory markers such as iNOS.