The problem is that the autoimmune threory has been maintained for 60 years, since the advent of EAE-- and this was a wrong turn. Neurology, (like a spouse who has gotten lost due to one wrong turn an hour prior), refuses to turn the car around and admit making an error. They're just too far down the road.
But the immune reaction of MS occurs in other cerebrovascular diseases.
Myelin antigen reactive T cells in cerebrovascular diseases
T cell reactivities to the putative autoantigens myelin basic protein (MBP), MBP peptides with amino acid residues 1 10-128 and 148-165, and myelin proteolipid protein (PLP) were examined in patients with acute ischaemic cerebrovascular disease (CVD) and, for comparison, in patients with
inflammatory neurological diseases and other neurological diseases. A quantitative measure of these T cell reactivities was obtained by assessing numbers ofT cells among blood and cerebrospinal fluid (CSF) mononuclear cells that secreted IFN-y in response to antigen in vitro. Higher numbers ofT cells reactive with each of these four antigens were detected in peripheral blood from patients with CVD compared with patients of the two control groups. Among blood cells from the CVD patients, their average number was 2-3-4-2/105 mononuclear cells. MBP reactive T cells were several-fold enriched in the CSF of CVD patients. The findings strongly suggest that brain damage in context with acute CVD leads to an in vivo expansion of myelin reactive T cells.
The same immune reaction occurs in stroke, cerebrovascular disease and other vascular "events". MBP and IgG are found in CSF of those with stroke, Alzheimers. A vascular condition, like CADISIL or CCSVI, is an ongoing onslaught, and would explain the continuing demyelination. It is not an immune system gone awry, it is an immune system dealing with an ongoing disease process.