8O I didn't know that, that's crazy.
To avoid IRIS, it is good to switch directly from Tysabri to an interferon. Perhaps later the interferon could then be discontinued? There is some research supporting this strategy.
Guys, this thread is just turning into a very scary one...
(None of your faults, just life, of course...) I've been on Tys for more than a year (OMG, coming up to a year and a half) and in a way I'm a big fan; before Tys I used to have relapses every 3-4 months and now I haven't had one since I'm on it.
I'm gonna have the procedure in a few weeks' time and hopefully everything will go really well. (I certainly prepare for best-case-scenario...) And I was also hoping that a few months later I might be able to come off Tys - like everyone else, I'm scared of PML... So this was the plan, and I did know about the fact that some people might rebounce but this IRIS-thing is completely new to me... I've only heard of IRIS in relation to PML, not when coming off the drug.
I know that here in the UK when you come off Tys they don't allow you to start something else immediately (at least not in my hospital), only if you have a few months (perhaps 3?) wash-out period first.
It would be lovely to hear of people who used to be on Tys, had the procedure done and came off it. I think Kerri and Loobie have done it but if there is anyone else, please, please share your story.