frodo wrote:I was reading the McDonald criteria and I was surprised by this paragraph, into the requirements for diagnosis (See http://www.msdiagnosed.org/McDonald.pdf , page 125, second column, second paragraph):
No Better Explanation
The Panel emphasizes that, even if the clinical evidence
and paraclinical studies are strongly indicative of MS,
there must be no better explanation for the clinical and
paraclinical abnormalities than MS for a secure diagno-
sis to be made.
At this moment there is at least the Putnam experiment with dogs and the new mouse model of CCSVI that produce demyelination. There is also the mind impaiment in CCSVI (http://ccsvism.xoom.it/ISNVD/Abstract-Hubbard.pdf) and the fatigue effect (http://www.ncbi.nlm.nih.gov/pubmed/20351673)
Therefore it can be said that CCSVI explains the clinical and paraclinical abnormalities found, and therefore, according with the "gold standard", any person shown to have CCSVI should get the MS label removed.
Anybody disagrees with this?
drsclafani wrote:the case i just reviewed on DSASQ was really interesting. seems like a case of ehlers danlos masquerading as ms....hopefully we will get an answer some day
I disagree Frodo. You seem to failing into the same hole that the neuros fell into with the immune theory. Neuros say MS is immuno and nothing else. You seem to say MS is vascular and nothing else. Both ideas are wrong.
MarkW wrote:MS simply means multiple lesions, Frodo. That is the definition of our disease. Historically a diagnosis could only be certain on death, when the brain could be sectioned and stained. Nowadays MRI shows lesions before we die. Not a lot of progress in 150 years !
I suggest that the clinical criteria are only useful for neuros. I agree with you, to change the name MS needs a better one to come along - Multiple Causes or Multiple Factors or ?. We just have to live with Multiple Sclerosis............deep joy.
MarkW wrote:A group of neurologists lead by McDonald changed the clinical condition, and call the "clinical definition" the McDonald criteria.....
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