Immunohistochemical study of vascular injury in acute MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Immunohistochemical study of vascular injury in acute MS

Postby Cece » Thu Apr 07, 2011 3:37 pm

J Clin Pathol 1994;47:129-133 doi:10.1136/jcp.47.2.129

Immunohistochemical study of vascular injury in acute multiple sclerosis.

A J Wakefield, L J More, J Difford, J E McLaughlin

Academic Department of Medicine, Royal Free Hospital, School of Medicine, London.


AIMS--To examine the vascular changes occurring in three archival cases of acute multiple sclerosis, and to provide immunohistochemical evidence of early endothelial cell activation and vascular occlusion in this condition.

METHODS--Central nervous system tissues from three cases of acute active multiple sclerosis and six non-inflammatory controls were stained using the following methods: haematoxylin and eosin, Luxol fast blue, cresyl violet, Bielschowsky's silver, and reticulin. Tissues were also immunostained with specific antibodies against collagen type IV, factor XIIIa, class II antigens, glial fibrillary acidic protein, and fibrinogen.

RESULTS--Early vascular endothelial cell activation which may progress to vasculitis and vascular occlusion including class II antigen expression and fibrin deposition were identified. The vascular changes were seen prior to cerebral parenchymal reaction and demyelination, and were not seen in control cerebral tissues.

CONCLUSION--It is proposed that vascular endothelial cell activation may be an early and pivotal event in the evolution of multiple sclerosis, and that demyelination may have an ischaemic basis in this condition. The vascular endothelium may contain an early element in the evolution of multiple sclerosis.

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From 1994. Certainly fits with CCSVI.
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Re: Immunohistochemical study of vascular injury in acute MS

Postby frodo » Fri Apr 08, 2011 12:14 am

Another great article!! Thanks.
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