Dr. Mehta's research findings

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Dr. Mehta's research findings

Postby Cece » Thu Apr 14, 2011 5:40 pm

Dr. Mehta's abstract:
A Prospective Analysis of Endovascular Treatments of Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis.

Authors & Affiliation: Mehta, Manish; Roddy, Sean P.; Chang, Benjamin B.; Darling, R Clement; Ozsvath, Kathl...een J.; Sternbach, Yaron; Taggert, John B.; Paty, Philip S.; Byrne, John; Kreienberg, Paul B.; Shah, Dhiraj M. Albany Medical College/Albany Medical Center Hospital, The Institute for Vascular Health and Disease, The Vascular Group PLLC, The Center for Vascular Awareness, Inc.

Introduction: Recently an association has been made between Multiple Sclerosis (MS) and Chronic Cerebrospinal Venous Insufficiency (CCSVI) characterized by stenosis and reflux of the principal extracranial venous drainage including the Internal Jugular veins (IJV) and the Azygous veins (AV). This prospective study evaluates the safety, feasibility, and efficacy of percutaneous transluminal angioplasty (PTA) of extracranial venous stenosis and its influence on the clinical outcomes of MS.

Materials & Methods: 150 MS patients underwent a detailed evaluation of bilateral IJV and AV via selective venography, and patients with angiographic evidence of >50% venous stenosis underwent PTA. Clinical evaluation included MS Quality of Life (MSQOL), and Modified Fatigue Impact Scale (MFIS) at 3, 6, and 12 months. The study was conducted with IRB approval and statistical analysis was performed using two-tailed Student’s t-test.

Results: Venography in 150 MS patients identified 267 central veins with >50% stenosis in the IJV (n=240/267, 90%) and AV (n=27/267, 10%), accounting for mean 1.8 lesions per patient. In treating IJV and AV lesions, PTA was technical feasible in 97%, technical successful in 77% (<20% residual stenosis), and 9% of lesions required re-interventions over a mean follow-up of 4 months. MS patient clinical evaluation indicated a significant improvement in the mean MSQOL Physical Health Composite scores (pre-PTA: 40.2 vs. post-PTA: 59.2, p=0.002), MSQOL Mental Health Composite scores (pre-PTA: 52.7 vs. post-PTA: 70.5, p=0.006), and Modified Fatigue Impact Scale (pre-PTA: 15.8 vs. post-PTA: 12.2, p=0.001).

Discussion & Conclusion: Results of this prospective study suggest an association between MS and CCSVI. PTA of venous stenosis in MS patients with CCSVI is feasible and safe, and results in significant clinical improvement as indicated by MSQOL and MFIS parameters. These findings need to be substantiated with future randomized blinded controlled trials that evaluate endovascular and surgical options for treatment of CCSVI.

For anyone too concerned about the 56% finding of CCSVI in MS patients using ultrasound, here is a much higher percentage found in MS patients using gold standard venography, by Dr. Mehta of Albany, NY.
Cece
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Postby fiddler » Thu Apr 14, 2011 6:56 pm

Cece, could you post the link, as well? Thanks.
...Ted
Dx SPMS in 2004.  Liberated 29/04/2010.
My blog: www.my-darn-ms.blogspot.com
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Re: Link

Postby frodo » Fri Apr 15, 2011 1:48 am

fiddler wrote:Cece, could you post the link, as well? Thanks.
...Ted


I have found an abstract here:

http://ccsvism.xoom.it/ISNVD/Abstract-Mehta.pdf

But there is no reference to where it was published
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Postby Cece » Fri Apr 15, 2011 7:05 am

It was one of the ISNVD abstracts. Thanks frodo for finding that link.
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