If MS comes first, then why do some people in the normal population have CCSVI? How did they get it if they don't have MS??
If MS comes first, then why are doctors finding congenital truncular venous malformations in people with CCSVI? Why are they finding webs, septum, upside down valves? How could MS create these congenital malformations?
If MS comes first, how does it make a vein disappear?
If MS comes first, then why did Dr. Dake find CCSVI in a woman whose Mom had MS? He diagnosed her with CCSVI before she ever got an MS diagnosis. Dr. Zivadinov did the same thing....he tested a daughter of a woman with MS in the Buffalo study. She was in the "normal" group. She had CCSVI and developed MS months later. Why?
If MS comes first, it would be the only vascular disease created by an unknown, incurable autoimmune illness. Budd-Chiari, a venous disease of the liver, starts with venous obstruction which leads to liver damage. May-Thurner, the disease of the legs, starts with a venous obstruction. All other diseases of venous congestion begin with a venous obstruction. As a matter of fact, they all have the EXACT same venous malformations being found in CCSVI.
If MS comes first, then why are other researchers studying neurodegenerative diseases finding links to the vascular system? In recent years, Alzheimers, dementia, Parkinsons are all being looked at as potential diseases of impeded cerebral bloodflow.
If MS comes first, then why does the immune system act the same way in other neurovascular disease? Why do t-cells attack myelin basic protein in the same manner in stroke, dementia, and other ischemic events in the brain? What would make MS so unusual that it could activate the immune system and create congenital venous malformations, as well?
The truth is, there is no plausible explanation for how MS could cause CCSVI. Ask a vascular doctor....they'll tell you they've never seen anything like it in any other venous disease.
Ockham's Razor comes to mind---it is a principle that generally recommends selecting the competing hypothesis that makes the fewest new assumptions, when the hypotheses are equal in other respects Accepting that MS causes CCSVI makes too many new assumptions that are not compatible with the current, known research.
And the most recent research out of BNAC...the first paper of the angioplasty study, found CCSVI in pwMS was related to truncular venous malformations in every patient. Webs, septum, inverted valves, agenesis...these are the same congenital venous malformations found in Budd-Chiari and May-Thurner, and they are present at birth. MS does not cause these venous diseases....here's the paper:
link to new BNAC research