I think I remember you from the patient testimonials on www.CCSVI.org
I am happy for you to be able to get retested and hopefully this "repair" will last for a good long time.
My theory is that Endothelin1 ( a polypeptide) that is made by the endothelium is over secreted due to the vein anomalies.
E1 production is triggered by hypoxia, hypoglycemia and disturbed sheer stress ( turbulence)- this sounds like CCSVI TO ME.
E1 is one of the strongest vasoconstrictors known. It can cause fibrosity ( stiffening) and hypertrophy (thickening) which re-models the vessel walls. Endothelin1 is found to be hundreds times higher than normal in pwMS per a study from 2001. This may be due to CCSVI.
I don't know how long E1 stays in the body. And if the cerebral hypoxia, hypoglycemia and sheer stress are eliminated ( by venoplasty) does the bodystill continue to make too much E1?and for how long ?
Can driving up your NO (nitric oxide) level -(a potent vasorelaxor) can we
drive the E1 level down to normal ? Exercise drives the NO level up in a healthy way. So maybe all patients need exercise programs to enhance this?
May there are safe drugs to lower E1 or ways to lower it that will improve the vein repairs in the future.
This just reinforces the need for research dollars in CCSVI RESEARCH.
Thanks for being one of the early pioneers.