Look at my Labs. Hypercoagulation needs to be addressed

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Look at my Labs. Hypercoagulation needs to be addressed

Postby LymeNurse » Thu May 05, 2011 6:57 am

There are great Panels from Esoterix.com that can be ordered and Drawn from Labcorp. Labcorp owns Esoterix. Thats where these labs came from below. This is why small doses of Lovenox, what have you are not going to cut it. If they do and you go off of them, then your problem comes right back.

This is why you will Restenose or Thrombose post CCSVI repair if not addressed. I'm not sure how much clearer I can make this folks. Get tested !

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Postby bluesky63 » Thu May 05, 2011 1:10 pm

Forgive me for saying that is cool, because it isn't cool to have abnormal clotting, but what a great piece of information. Thank you for posting this.

And can any lab test for it if they have the right codes?
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Postby LymeNurse » Thu May 05, 2011 1:29 pm

Here are some great test codes. They can all be drawn at Labcorp, but some are sent out to Esoterix from Labcorp after they draw them.

Esoterix
Test Code:
501790- Venous Thrombosis Profile
Test Includes: Activated partial thromboplastin time (APTT); anticardiolipin antibodies IgG, IgM; antithrombin activity; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; factor II gene mutation; factor VIII activity; hexagonal phospholipid neutralization; homocysteine; protein C activity (chromogenic); protein C resistance with factor V deficiency; protein S antigen, free; β2-glycoprotein I, IgA, IgG, IgM

500700- Fibrinogen Evaluation Profile III
Test Includes: Fibrinogen activity; fibrinogen antigen; reptilase time; thrombin time; thrombin time--heparin neutralization

501056- Antiphospholipid Syndrome
Test Includes: Activated partial thromboplastin time (APTT); APTT 1:1 NP; APTT 1:1 saline; anticardiolipin antibody, IgG; anticardiolipin antibody, IgA; anticardiolipin antibody, IgM; antiphosphatidylserine, IgG; antiphosphatidylserine, IgM; antiprothrombin antibody, IgG; antiprothrombin antibody, IgM; β2-glycoprotein I, IgA; β2-glycoprotein I, IgG; β2-glycoprotein I, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; dilute Russell's viper venom time (dRVVT) screen seconds; hexagonal phospholipid neutralization; lupus anticoagulant interpretation; platelet neutralization


Labcorp
337398- Thrombotic Risk Profile, Comp. Test Includes: Activated protein C resistance (APCR); anticardiolipin antibodies, IgA, IgG, and IgM; antiphosphatidylserine, IgA, IgG, and IgM; antithrombin antibodies, IgG and IgM; antithrombin activity; β2-glycoprotein 1 antibodies, IgA, IgG, and IgM; dilute prothrombin time profile; factor II (prothrombin) mutation analysis; lupus anticoagulant with reflex; methylenetetrahydrofolate reductase (MTHFR) thermolabile variant, DNA analysis; plasminogen activity; protein C, functional; protein S antigen, free
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Postby Filmmaker » Thu May 05, 2011 2:25 pm

wow!! Interesting!! Any idea what causes the blood to hypercoagulate? I know you have lyme but Msers have that pb too...
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Postby bluesky63 » Thu May 05, 2011 2:40 pm

Well, I think this is one explanation:

http://www.anapsid.org/cnd/diffdx/hypercoagulation.html
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Postby Filmmaker » Thu May 05, 2011 2:58 pm

thanks blue sky, but could this blood cotting issue be also "auto immune", from my understanding it is first a defesive mechanims of the body until toxins are processed...
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Postby HappyPoet » Thu May 05, 2011 3:01 pm

LN, WOW! Thanks very much for teaching us about Lyme and hypercoagulation. I will definitely be following up with this testing. I just finished reading all your posts/threads -- thank you for sharing all your information.

Bluesky, the study you linked to is fascinating and helps explain many things. Thanks!
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Postby LymeNurse » Thu May 05, 2011 4:05 pm

I've read many articles on the Hypercoagulation theories, but I never saw this one. The cause is obviously related to Bacterial invastion. The Anti-Thrombin mechanism sure makes sense.

So hard to get whether or not this is actually backed up with real science or not. As there are no "Studies" yet lots of Theories floating around.

So here we have other illnesses that are once again Lyme disease If you want the long laundry list, I will give it to you guys, but basically, all diseases that have a Neuro component yet can NOT be tested for are thought to be Lyme disease.

Michael J. Fox is a perfect example: He had Lyme disease not long before he developed Parkinsons. My Lyme Dr. has had a few people diagnosed with Parkinsons and has gotten them well with Antibiotic therapy.

If you look at this article, at the top it talks about "Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more..." The Author speaks about how he was treating his Lyme disease and needed very high doses of Heparin.

FYI, Hemex labs is owned by Esoterix, which is owned by Labcorp. Just thought I'd throw that in there since they are tossing around testing costs that most don't have.

Anyway, they mention Natokinase, but not Lumbrokinase which I find interesting since Lymbrokinase TPA like activity is 20 times more portent then that of Natokinsase. Chinese studies do back this up.

I'm sticking with Boluoke with is pure Lumbrokinase and I hope to report symptom relief soon. I just found another Lymie with CCSVI today who is scheduled for surgery tomorrow. I warned her of the Herx reaction she may get and not to expect the MS type relief.

Again, Lyme patients avoid immune suppression at all costs while MS does not. So we go into surgery with inflammation from our Lyme where MS has it under control. Immune suppression may via Steroids may be a good option for Lyme patients that can't get well from Antibiotics or Alternative treatment since many issues seem to surround inflammation. At least, quality of life is restored to some degree.

If were hoping for the immune system to assist us in recover then obviously this is not a viable route.

Trust me when I tell you there is more going on then CCSVI and bacteria, Hypercoagulation, etc., but I would bet my life that the Lyme is behind it all.

I'm glad were having healthy discussions here and everyone is being open minded. In the Lyme community, everyone would be jumping over each other with their opinions about the writers in these posts. They call it Lyme rage. I don't see it here since I've been posting and it's nice to be able to express my thoughts to you guys. I think I like it better over here :-)

In the end, we are our own Dr.'s , Scientists, etc. to a large degree, so keep up with the researching folks.
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Postby Cece » Thu May 05, 2011 4:11 pm

I just found another Lymie with CCSVI today who is scheduled for surgery tomorrow. I warned her of the Herx reaction she may get and not to expect the MS type relief.

I am curious to hear if she gets the Herx reaction too. I wouldn't wish it on anyone from the sounds of it but I think your theory of it being because the blood flow is suddenly washing the backlog of toxins out of the brain is a viable theory.
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Postby Filmmaker » Thu May 05, 2011 4:23 pm

About the herx reactions, many MSers choose to go the antibiotics route ans they do herx as much as those with lyme... For more info you can check www.CPn Help.org
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Postby bluesky63 » Thu May 05, 2011 5:00 pm

About the steroids . . . lyme-literate doctors steer lymies away from steroids because they suppress symptoms but do nothing to get rid of the little buggers. :-) Many lymies say steroids ultimately make their recovery longer, harder, more protracted. There are natural ways of calming the brain and immune system that do not involve steroids.
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Postby LymeNurse » Thu May 05, 2011 6:06 pm

Only looking at your Profile pic. would give me even the slightest calming.. What else are you referring to ?

Myself and a few others have off the wall Anxiety that Xanax doesn't even come close to touching. I take Klonopin 2 x day and even still it doesn't barely touch it.

Most of us can't tolerate SSRI's, they don't work for this kind of anxiety. Our crying is 2 y.o. Neurological type as if we had a stroke or something. AD's don't work for that either.

So, we take breaks from treating for relief or we would keep going... Would love to hear your suggestions as most of us have tried everything out there.

I did tons of research on Natural approaches.. We don't even know what is out of Kilter. It's def. not Serotonin.
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ccsvi

Postby blossom » Thu May 05, 2011 6:08 pm

thank you lymenurse for shareing all this. i hope you feel better.
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Postby Bethr » Thu May 05, 2011 6:22 pm

Very interesting lymenurse. I have thick blood, I'm just waiting for an appointment with a hemotologist (second opinion). My hemoglobin is above range (again), as is hematocrit, platelets, white cells and lymphocytes. Each time I get a phlebotomy, it thins my blood, all those numbers come down to normal range, removes iron and I feel great, it just doesn't last too long, maybe six weeks, and then I go backwards again as my blood thickens. But have to say each time my ferritin goes down I feel better and better.

I'm hoping they will test me for the JAK2 gene.
Most people with polycythemia have this.
Recent studies show Polycythemia causes hypoperfusion in the brain when hematocrit is over .46. I'm currently sitting at 47.5.
Treatment is mainly by bloodletting to get the iron levels down and help stop the over production of red blood cells. I'm due a phleb in 6 days, and it's been a long 12 weeks wait this time!

I developed a brain lesion/epilepsy when my iron levels were at mild iron overload levels in 2008 (62% transferrin saturation, ferritin 175). No more brain events since then other than Chorea in early 2010. The relief from the fatigue and brain fog is almost instant when the blood is thinned. Like magic.
I also feel very calm and measured.


http://www.clinicalcorrelations.org/?p=2975
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Postby LymeNurse » Thu May 05, 2011 7:28 pm

Bethr,

I was just reading up a bit more on your condition. Funny, as I use to do these therapeutic phlebotomies for my patients on the side for a homecare company.

I never knew I was actually thinning the blood, but rather reducing blood volume. I guess it makes sense since your pulling off platelets, RBC's, WBC's, etc.

There is a platelet reducing drug called Anegrelide. Have you ever tried a drug such as this or even Plavix ? I wonder if Boluoke would be good for you too.

If your trying pharmaceuticals for this, please do read up on Boluoke. I wouldn't be surprised if this too were a Lyme symptom.

They don't call Lyme the "Great Mimicker" for nothing.

Have a great night...

Gary
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