Internal jugular vein valves in healthy subjects

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Internal jugular vein valves in healthy subjects

Postby Cece » Sat May 14, 2011 12:08 pm
Ital J Anat Embryol. 2010;115(3):185-9.

Internal jugular vein valves: an assessment of prevalence, morphology and competence by color Doppler echography in 240 healthy subjects.

Valecchi D, Bacci D, Gulisano M, Sgambati E, Sibilio M, Lipomas M, Macchi C.
SourceDon Carlo Gnocchi Foundation, IRCCS, Florence, Italy.


The presence of valves in the head and neck veins is known since classical anatomical dissections. Previous studies have investigated whether jugular veins show constant valves at their ostium and whether these valves are physiologically competent, but, unluckily, these studies have reported conflicting results. Further, recent observations have raised the question whether the incompetence of jugular vein valves might play a pivotal role in neurological disorders related to venous engorgement of the brain. In this study we examined 462 internal jugular veins by using an echocolorodoppler apparatus. In particular, we assessed the presence, morphology and competence of valves at their ostium. Unilateral jugular vein valves were present in 406 cases (88%), mainly on the right side. The most frequently observed morphology (75%, 305 cases) was the two-leaflet valve, and jugular vein valves were incompetent in the huge majority of cases (365 cases, 90%). Our findings confirm the anatomical variability predicted from classical anatomical studies but, unluckily, do not provide additional evidence on the possible role of jugular vein valves in physiology and pathology. Further studies are strongly needed to determine whether these valves actually play an important role in counteracting chest venous pressure and in preventing reflux towards the brain.
Family Elder
Posts: 9302
Joined: Mon Jan 04, 2010 3:00 pm


Postby 1eye » Sat May 14, 2011 4:22 pm

jugular vein valves were incompetent in the huge majority of cases (365 cases, 90%)

It's probably a pretty good thing most folks don't spend much time upside-down these days. Still room for a genetic wrinkle like CCSVI coming from a specific kind of malformed valves: more likely in some segments of the population perhaps? Combines with some other plumbing peculiarity that can be remedied, maybe? With some kind of intervention other than a balloon or a stent?
This unit of entertainment not brought to you by FREMULON.
Not a doctor.
User avatar
Family Elder
Posts: 3725
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada

Re: Internal jugular vein valves in healthy subjects

Postby Cece » Tue Feb 11, 2014 7:22 am

More research on the topic of jugular vein valves in healthy individuals from a presentation at ISNVD 2014
(click on the presentation book pdf here for the source) ... -book.html
What is the Normal Jugular Vein Valve Function?

Erica Menegatti, M.D. & Ph.D.*, S. Gianesini*,M. Tessari*, ME. Vannini*, F.Sisini°, P. Zamboni*. *Vascular Diseases Center, University of Ferrara, Via Aldo Moro 8, 44124 Cona (FE), Italy Department of Medical Physics, University of Ferrara Italy

Objective: The internal jugular vein (IJV) valve opening and closure mechanism in relation to the posture and respiration is not fully understood so far. Therefore, an accurate ultrasound characterization of the IJV valve physiologic function becomes necessary.

Methods: Eighty-three (83) consecutive healthy volunteers (35 Male, 48 Female, 25.7±6.7 y.o.) underwent to high resolution B and M-mode evaluation of IJVs junction valve plane, in standardized respiratory conditions.

Results: The valve absence was found in 34% on the right and in 43% on the left. A mono-cusp valve was demonstrated in 19% and in 35%, a bicuspid in 47% and in 22%, a tricuspid in 0%, respectively on the right and left IJV. In supine, the leaflets were always mobile with synchronous opening in relation either to right atrium contraction or respiration. In upright an area reduction of about 50% was recorded, and the valve remains open in any respiratory phase.

Conclusions: The absence of IJV valve in a relevant number of healthy subjects suggests a progressive lost of importance of such apparatus. In physiology, the valve leaflets are always mobile with bicuspid predominant shape, mono-cusp is possible, but tricuspid was never seen

See, there's something I didn't know. In the healthy individuals, the valves were always mobile when the individual was lying down but the valves remained fully open when the individual was upright.

In the healthy individuals, the valve leaflets were always mobile. This was in a sampling of 83 volunteers.

I immediately compare this to my own real-life example, when I had my ultrasound done and it was seen that the valve leaflet in my left jugular was completely immobile. This is not what's seen in healthy individuals. And it was treatable. Yay.
Family Elder
Posts: 9302
Joined: Mon Jan 04, 2010 3:00 pm

Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)


  • Related topics
    Last post

Who is online

Users browsing this forum: No registered users

Contact us | Terms of Service