VIAGRA COULD REDUCE MS SYMPTOMS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby dlynn » Wed Oct 19, 2011 9:03 pm

If Viagra increases blood flow to the brain, would stenosis or other obstruction make it more difficult for
the blood to return to the heart? Does it open all vessels?
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby goonasi » Fri Nov 04, 2011 4:06 am

dc10 wrote:has any other men tried Cialis on a daily casis?

what daily dose? what results did you notice?

i am going to start a 2 week trial of cialis but not sure of what dose?
also what risks am i taking by using a daily dose of cialis for 2 weeks?

thanks


Have you started your 2 week trial yet?

If so any encouraging results?

Cheers Si
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby dania » Fri Nov 04, 2011 7:27 am

I tried Cialis, 4 consecutive days. It did help. I was stronger. And that internal vibration was much much less.
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby Algis » Fri Nov 04, 2011 8:37 am

I have tried Cialis - 20mg pill (for what it supposed to be made) and what I noticed was an horrible headache for 2 days... I did not even wake up the first morning. I can't confirm/infirm the energy increase.
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby Cece » Fri Nov 04, 2011 10:22 am

I would think that, for CCSVI, it would make sense to try the low-dose version of Cialis that's meant to be taken daily. It's 2.5 mg or 5 mg instead of 20 mg.
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby dania » Fri Nov 04, 2011 10:49 am

Mine was 20mg/tablet. Well tolerated. Noticed heart rate increase with the first tablet but with the others it did not happen.
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby questor » Fri Nov 04, 2011 2:16 pm

Algis wrote:I have tried Cialis - 20mg pill (for what it supposed to be made) and what I noticed was an horrible headache for 2 days... I did not even wake up the first morning. I can't confirm/infirm the energy increase.

That was my experience also, hence my earlier comment about headaches. But, this occurred with the 3-day pill (I don't remember the dose), so I'm willing to give the 2.5mg daily dose a try. I've scheduled an appointment to meet with a urologist next Monday to get a script for this.

I already inject prostaglandin to treat ED, and so the cialis may provide an added benefit apart from promoting improved cerebral bloodflow (that is, potentially the need for fewer injections). I currently take 10mg vinpocetine twice daily, a PDE type-1 inhibitor. Cialis is a PDE type-5 inhibitor, with supposed similar improved cerebral bloodflow characteristics.

--Tracy
CCSVI Procedure 9/16/2009 at Stanford
Stent in left and right IJVs
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby Cece » Fri Nov 04, 2011 2:38 pm

http://www.sciencedirect.com/science/ar ... 5708003420
Tadalafil [Cialis] improves short-term memory by suppressing ischemia-induced apoptosis of hippocampal neuronal cells in gerbils
Tadalafil treatment improved short-term memory by suppressing ischemia-induced apoptotic neuronal cell death in the hippocampal CA1 region, and decreased cGMP level. Also, tadalafil suppressed the ischemia-induced increase in cell proliferation in the hippocampal dentate gyrus. We showed that tadalafil can overcome ischemia-induced apoptotic neuronal cell death, thus facilitates recovery following ischemic cerebral injury.

MS may be similar to recurrent small ischemia attacks, and Cialis might be protective in that regard.
This was research in gerbils.

another one:
http://informahealthcare.com/doi/abs/10 ... 010.492061
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Re: VIAGRA COULD REDUCE MS SYMPTOMS

Postby Cece » Fri Nov 04, 2011 2:43 pm

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851459/
Suggested doses in various clinical studies (15,25) that exhibit beneficial activity of PDE inhibitors include sildenafil (Viagra) 50 mg twice daily, vardenafil (Levitra) 10 mg twice daily, and tadalafil (Cialis) 20 mg every two to three days, although further studies are needed to delineate optimal dosing suggestions.

So for the full dose, it might be taken every 2 - 3 days and you'd get the benefits of having it in your system.

http://www.ncbi.nlm.nih.gov/pubmed/16835313
Available evidence suggests that sildenafil may be associated with improved microcirculation, symptomatic relief, and ulcer healing in patients with secondary Raynaud's phenomenon. Limited information suggests similar effects with tadalafil and vardenafil. Improved blood flow and clinical improvements have also been observed in some patients with primary Raynaud's phenomenon treated with PDE5 inhibitors; however, studies have yielded conflicting results.

There has been research on the use of sildenafil for patients with Raynaud's phenomenon, which is sometimes secondary to MS, so something to consider for anyone who has Raynaud's as well.
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