Here is a pdf of a presentation Dr. Kirsch did this month on CCSVI at the VIA Foundation 3rd Annual Women’s Health Symposium in Buffalo, NY:
No one cause
–No one cure
Different people have different spectra
–Heterogenous response to treatments
Abnormalities can be seen in normals
I hadn't heard the term spectrum disorder before but it fits.
Confirm Dx of MS
History and Physical
–Include metrics of MS
Evidence of other vein disease (espM-T)
Non-invasive imaging not yet helpful
Non-invasive imaging not yet helpful? Does VAC do a pre-procedure ultrasound?
Gold standard for evaluation
Diagnosis and treatment at same sitting
Evaluate IJVs and Azygosvein
? IVC Confluence, Renals
This too makes me wonder if they do pre-procedure imaging. I find pre-procedure imaging to be a good thing for comparison to post-procedure imaging but hard to say.
Dr. Kirsch has been said to be using the "McGuckin Protocol" which we determined in another thread to mean checking not just the IJVs and azygous but also the renal veins and IVC. Dr. McGuckin has ballooned a number of patients renal veins, interpreting them as 50% blocked; Dr. Sclafani has only ballooned one patient's renal vein.
Ballooning unnecessarily could cause damage; not ballooning if it is a stenosis could leave it untreated. The azygous can drain into the renal in some anatomical variants so that is why a blockage there could affect CCSVI.
Look at both anatomy and flow
–Delay, turbulence, collaterals
–Sometimes need high pressure balloons
–? Utility of cutting balloons/valvulotomes
–Lesions resistant to PTBA
Helpful for knowing what techniques he may use. PTBA means balloon angioplasty. It sounds like Dr. Kirsch will use high pressure balloons sometimes and stents if ballooning does not work but is unsure of the use of cutting balloons. Here he uses the term 'bailout' which is also on Dr. Sclafani's symposium list-of-topics, I need to get a precise definition of that term!
Impression from carotid bulb
Impression from bone spurs
Compromise by muscle slips/fibrous bands
? Surgical release
He's familiar with the concept of extravascular or physiological narrowing. I can't tell from this if he would stent these or not. Dr. Sclafani has called narrowing from the carotid impression a leave-me-alone lesion.
About 1/3 of patients have MAJOR symptom improvement
–Often almost immediate
This is the 1/3rds, 1/3rds, 1/3rds that Dr. Siskin often discusses. I would assume that if Dr. Kirsch is mentioning it, he is seeing these results as well in his patients at about these percentages. He goes on to say the 1/3 mild, 1/3 no improvement.
In the same google search that turned up this pdf, it turned up the ISET newsletter which mentioned this non-CCSVI research:
The results of a randomized
trial to study the performance of
two leading bland embolics have
demonstrated equivalent outcomes
between the two products
used.1 The trial, published on line
by the Journal of Cardiovascular and
Interventional Radiology (CVIR) in
December 2010, was led by Robert
Worthington-Kirsch from the
Peripheral Vascular Institute of
Philadelphia with colleagues Gary
Siskin and Paul Hegener from a
second center, Albany Medical
College, New York, and involved
I mention it because it shows that Dr. Kirsch and Dr. Siskin have worked together. Seeing Dr. Siskin's 'thirds' stated in Dr. Kirsch's presentation also shows a cross-fertilization of ideas between the two. This is a good thing as Dr. Siskin has a great deal of experience with CCSVI at this point.
–? Dependent on vessel treated
–? Recurrence of symptoms associated with recurrence of lesion
Dr. Cumming has been saying that durability is important and where we'd like to see advances. Dr. Kirsch raises two good questions about durability.
Sort signal from noise
–Real treatment effect vs Placebo effect
–Who is or is not a candidate
–Timing of treatment
–Predictability of outcomes
–What is a lesion
–How to treat
A Very Long Post, I know, and I hope someone comes along with actual experience with the doctor. But I found his presentation materials of interest and it shows he has an understanding of CCSVI.