Multiple sclerosis and chronic cerebrospinal venous insufficiency: a critical review
Amer M Awad, Ellen Marder, Ron Milo, and Olaf Stuve
Therapeutic Advances in Neurological Disorders published online 10 May 2011
Based on conflicting published data, it is currently unclear whether CCSVI exists as a pathologic entity, or as an anatomic variant in patients with MS. It is even less substantiated that there is a causal association between CCSVI and MS.
Based on a review of the literature, it is our view that the concept of CCSVI is inconsistent with the epidemiology, pathology, and many of the clinical features of MS. Pending further investigations, no therapeutic interventions involving treatment of plausible CCSVI should be recommended for patients outsie of controlled clinical settings.
It's interesting, from my own experience and my knowledge of the MS literature, CCSVI is consistent with the epidemiology, pathology, and many of the clinical features of MS. That last one especially. There has been much unexplained by the autoimmune theory that the CCSVI theory explains.