Don't know if this has already been posted :
MS Research Progress Takes Center Stage at American Academy of Neurology’s Annual Meeting
Here is the link to the report :
quote related to CCSVI :
Research Toward Restoring Function
— CCSVI and MS
Five studies, including three posters and two platform presentations, related to studies of CCSVI (chronic cerebrospinal venous insufficiency) and MS. Read more about CCSVI (MS Society of Canada: http://mssociety.ca/en/releases/nr_20100611.htm
Mei Lu, MD (Cleveland Clinic Cerebrovascular Center), a member of one of seven teams (http://www.nationalmssociety.org/news/n ... x?nid=3339
) being supported to investigate CCSVI by the National MS Society (USA) and the MS Society of Canada, was lead author of a poster on factors, both physiological and technical, that can complicate screening for vein blockages using Doppler sonography (ultrasound) technology:
They found that findings were often dependent on which operator conducted the ultrasound evaluation.
The team reported that heartbeat irregularities, stages of breathing, head position and pressure applied by the operator could alter results.
The team also reported that the state of hydration of the subject (whether they drank adequate amounts of fluids) could also impact results of several of the criteria used to determine CCSVI.
They concluded that these complications may help explain the mixed results reported thus far related to CCSVI and MS, and that having consensus guidelines would help improve the standardization of ultrasound assessments related to CCSVI. (Abstract P01.263)
A platform presentation by the team of Florian Connolly, MD (Humboldt University, Berlin) described a study that measured venous blood flow and narrowing with Doppler sonography in 96 people with MS (75 relapsing-remitting, 21 secondary-progressive) and 20 healthy controls.
As in a previous study published in 2010, in this larger sample of people they were unable to detect individuals who met more than one criterion for CCSVI.
Except for one person with MS, blood flow direction was normal in internal jugular vein and vertebral veins.
As in the previous study, the team found that blood volume flow tended to be higher in the upright position in people with MS compared to the healthy controls. (Abstract S01.001)
A poster from Yuval Karmon, MD, Robert Zivadinov, MD, and colleagues (University of Buffalo) focused on details from Phase I of what is planned as a controlled clinical trial of angioplasty to treat CCSVI (PREMiSe trial). This phase was an open-label evaluation comparing the use of three imaging methods (Doppler sonography, intravascular ultrasound, and catheter venography) to detect valve abnormalities of the internal jugular vein in 10 people with relapsing MS who fulfilled criteria for CCSVI.
They found that Doppler sonography was a sensitive tool for detecting internal jugular valve abnormalities, and that its findings were comparable to invasive intravascular ultrasound.
They found valve dysmobility frequently in this sample of patients diagnosed with CCSVI.
According to the investigators, the next phase will include more people and will be a blinded and controlled study of angioplasty. Results of that trial will be released after they have completed the study. (Abstract P04.187)
A platform presentation from Katayoun Alikhanim MD (University of Calgary) and colleagues from across Canada focused on a study of the frequency of neck vein abnormalities in 67 people who visited an MS clinic (34 MS, 20 not MS, 7 possible MS, 6 CIS) using contrast-enhanced MR venography.
The radiologist was blinded as to the condition of each patient.
Abnormalities were found in 7 out of 34 with MS, 4 out of 20 not MS, 0 out of 7 possible MS and 1 out of 6 CIS.
Those with MS with vein abnormalities were more likely to be older (average age about 52 years) and to have more disability (average EDSS 6.17) compared to those with normal veins (46 years, 3.57 EDSS). (Abstract S01.006)
A poster from Kresimir Dolic, MD, and colleagues (University of Buffalo) described a study to compare vein findings using Doppler sonography and MR venography and determine whether they were complementary. The study included 150 people with MS (104 relapsing-remitting, 38 secondary-progressive, 8 primary-progressive) and 63 healthy controls matched for age and sex.
They found that Doppler sonography was more sensitive for detecting internal jugular vein flow abnormalities, while MR venography was more sensitive for detecting collateral veins.
98 (67.12%) of people with MS and 18 (28.57%) of healthy controls met criteria for CCSVI.
People with MS had evidence of collateral veins more often than healthy controls. (Abstract P05.071)