Damaged cells spill out their contents, thus the Oligoclonal bodies normally inside myelin cells are found outside them.
Cece wrote:Damaged cells spill out their contents, thus the Oligoclonal bodies normally inside myelin cells are found outside them.
Post venoplasty, can the cells recover from this? The oligoclonal bodies wouldn't get back in, even if the damaged cells are healing. Can the cells make more of these?
These data indicate that while the EAE mouse model may mimic aspects of MS neuropathology which result from inflammatory demyelinating events, there is another distinct mechanism involved in mitochondrial dysfunction in gray matter in MS which is not modeled in EAE.
monik_77 wrote:Now I was thinking that if the mitochondria of oligodendrocytes are affected, probably the CCSVI treatment + mitochondria treatments could help us more. I just to find this website:
ozarkcanoer wrote:In all eucaryotic cells, the mitochondria organelles are responsible for generating energy in the form of ATP for the running of cell function. Part of the generation of ATP is to create an ion gradient across the wall of the mitochondrial organelle. This ion gradient is used to produce ATP from ADP and P+ (phosphorus). If there were something wrong with the biochemistry of mitochondria then perhaps not enough ATP energy would be produced. With a lack of energy a cell would be in trouble, maybe die.
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