When I wrote up the Endothelial Health program in '08 and shared it online, the premise was that there were many factors creating to the break in the blood brain barrier in pwMS. I looked at environmental issues that might create endothelial dysfunction, or a breakdown of the lining of our blood vessels. I hypothesized that this was why my husband had high liver enzymes, high coagulation numbers and petechiae and jaundice on his body, while he had his first MS flare. I believed that the breakdown of his vessels was systemic.
One of the factors I researched was low vitamin B serum levels (which he had also) creating high homocysteine levels in the blood, causing a breakdown of the endothelium and leading to a myraid of vascular problems. And vitamin B and B12 supplementation improves this vascular condition. Hope that provides some connection.
The research is based on a real white coat, Dr. John Cooke at Stanford, and his book The Cardiovascular Cure, although the connection to MS was just mine, a wanna-be white coat, actually...just someone who wanted to help her husband heal.
Here's the full protocol, with links to the research papers cited:
http://www.ccsvi.org/index.php/helping- ... ial-health