menopause and vascular changes

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

menopause and vascular changes

Postby Cece » Thu Jun 09, 2011 9:15 am

www.sciencedaily.com/releases/2008/06/080616153622.htm
In their study, MU researchers removed the ovaries of pigs, which have a reproductive cycle similar to humans, to create postmenopausal conditions. Two months after the ovaries were removed, they observed dramatic differences in the brain’s vascular system. There was a huge loss of micro vessels, and blood vessels became “leaky.”
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Postby munchkin » Thu Jun 09, 2011 9:31 am

That doesn't sound great for us women, I was looking forward to menopause.

Right now I need all of my micro vessels.
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Postby Cece » Thu Jun 09, 2011 9:58 am

Before menopause, the vascular system depends on estrogen for maintenance. When the body decreases its estrogen production, the body is unable to regulate blood vessels like it did before. After a period of deterioration, the body learns to adapt to the estrogen loss and eventually maintains the system in a different way.

It doesn't say what the different way is.

Blood vessels becoming leakier doesn't sound good either, particularly if our blood vessels are already leaky.
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Postby mavis » Thu Jun 09, 2011 2:23 pm

Oh, this is just what I needed to hear :cry:
After getting the very first signs just recently that I might be in the company of the "M" word in the not too distant future....

I wonder if low dose estrogen could be helpful.
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Postby ThisIsMA » Fri Jun 10, 2011 9:41 am

I wonder if low dose estrogen could be helpful.


The article Cece provided a link to discusses this. They seem to think that the body adapts naturally over time and that supplementing with estrogen might do more harm than good. But they are talking about healthy women, not WWMS.

Also in their study of the pigs, they didn't use pigs naturally going through menopause, they surgically removed the ovaries from the pigs, causing healthy young pigs to suddenly go through an artificial and extremely abrupt menopause. This might be very different then the gradual natural process women go through, where hopefully the body has time to adapt.

Still its disconcerting, and I'm planning to keep my vitamin D level near the high end of normal as one way to combat this, since according to research studies, vitamin D is a vasodilator.

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Postby PCakes » Fri Jun 10, 2011 12:18 pm

ThisIsMA wrote:But they are talking about healthy women, not WWMS.

Could this help to explain 'late onset'.. those presenting first symptoms at middle age?
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Postby 1eye » Sat Jun 11, 2011 5:46 am

There is a paper on Estrogen and HRT in the book I mentioned about Vascular Dementia. I scanned it, looking for clues on whether E2 or HRT influences blood supply. While it is clear that it does, I think they wanted to stay clear of any recommendation of HRT, and did mention some of its problems. http://www.thisisms.com/ftopic-16748-da ... sc-30.html
"Try - Just A Little Bit Harder" - Janis Joplin
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'MS' is over - if you want it
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Postby Cece » Sun Jun 12, 2011 7:35 pm

PCakes wrote:
ThisIsMA wrote:But they are talking about healthy women, not WWMS.

Could this help to explain 'late onset'.. those presenting first symptoms at middle age?

It could be a factor, I would think.
I'll look into this further, I hate to draw too many conclusions from a study on pigs. (1eye, I'll start with that link.)
There are many things we can do to improve endothelial health, even if menopause is a thing that is bad for us, it might be possible to compensate with other things (diet, laughter, sunshine, vitamin B12...basically whatever is on Cheer's endothelial health program!)
I felt bad having posted bad news about menopause. :(
With the discovery of CCSVI, we are in the midst of so much good news for people with MS, it is unprecedented.
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