http://swedish.org/About/Blog/May-2011/ ... -Sclerosis
A patient advocate who runs a Facebook CCSVI advocacy page with over 19,000 members and serves as a founding member of the CCSVI Alliance (ok, yes, it's Cheer) shares her response: <shortened url>
• CCSVI does not seem to explain the distribution of white matter lesions or the relapsing and remitting course that most patients experience
-If we hold CCSVI to this measure, perhaps we should hold the autoimmune theory to this as well?
CCSVI does explain the lesion distribution, since white matter lesions are perivenous (along the veins in the brain), which would certainly be in line with venous reflux and slowed venous drainage. In fact, Rindfleisch noted the tiny, engorged veins inside each white matter lesion while looking thru a microscope at an MS brain in 1863. Dr. Alfons Schelling writes of venous back pressure and the location of MS lesions in his book. http://www.ms-info.net/evo/msmanu/839.htm
Here is research from 2011 showing MS white matter lesions are perivenous in over 80% of those with MS:
-The relapsing-remitting nature of MS has NEVER been explained by MS specialists. As a matter of fact, the animal model of MS, EAE, is NOT relapsing and remitting, but constant, and more like ADEM in humans. That said, venous stenosis and reflux can be worsened in CCSVI by increases in hypoxic environments caused by viruses, colds, stress, high altitude, smoking--all situations which are known to exacerbate MS and possibly lead to relapses. How does the EAE model of MS explain relapses???