“To date we have studied 35 people with MS and 35 healthy control subjects, so we are just over one third of the way towards completion,” reports A/Prof Chambers. “Preliminary blinded analysis of the whole 70 cases, using the criteria proposed by Zamboni, indicates that CCSVI (chronic cerebrospinal venous insufficiency) is less prevalent than expected.” In fact, preliminary analysis has revealed that no subjects so far studied have CCSVI according to the criteria proposed by Zamboni. “Since our MS cohort are in the early stages of disease, this would imply that if CCSVI does occur in MS, it does not have a causal role, and it may only develop in more advanced MS,” explains A/Prof Chambers. “It is possible that CCSVI is mainly observed in advanced MS. This is supported by our observations in out-of-trial advanced MS patients.”
The investigators also plan to present these findings at ECTRIMS (Congress of the European Committee for Treatment and Research in Multiple Sclerosis) in Amsterdam, October 2011.
Well, we know what one of the studies presented at ECTRIMS this fall will say! Last year at ECTRIMS there were studies that found CCSVI and studies that didn't. More that did than that didn't, though. The year before, the only CCSVI at ECTRIMS was a poster by Dr. Zamboni. It's progress!