hope410 wrote:Rinsho Shinkeigaku. 2011 Jun;51(6):430-2
[Evaluation of blood flow and the cross-sectional area of internal jugular vein in Japanese multiple sclerosis and neuromyelitis optica patients].
[Article in Japanese]
Tanaka M, Uchizumi H, Tanaka K.SourceMS Center, Utano National Hospital.
Zamboni et al proposed a new hypothesis for the pathomechanisms of multiple sclerosis (MS): chronic cerebrospinal venous insufficiency (CCSVI).
Using Doppler ultrasound and venograms, they found severe extracranial venous stenosis in MS patients. They suggested that a venous obstruction in the neck caused a reflux back into the brain, which led to edema and demyelination.
We examined the blood flow and the cross-sectional area of the internal jugular veins using Doppler ultrasound (Vivid 7 PRO, GE Health Japan, Tokyo) in 17 MS (8 males and 9 females; 20-58 years of age, median 38 years) and 11 neuromyelitis optica (NMO) Japanese patients (1 male and 10 females; 23-60 years of age, median 44 years). Nine of the 11 NMO patients were seropositive for anti-aquaporin4 antibodies.
We did not find any obstruction or stenosis of the internal jugular veins in any patient. Other disorders such as bilateral internal and external jugular venous ligation or radical neck dissection, which result in venous stasis, are not known causes of demyelination in the central nervous system.
Our data also does not support the hypothesis of CCSVI theory, despite the fact that our study was limited to a small group of patients and the examination was performed only using Doppler ultrasound.PMID: 21735737 [PubMed - in process]
Devic’s neuromyelitis optica (DNMO) is a demyelinating and inflammatory disease of the central nervous system (CNS) essentially restricted to the spinal cord and the optic nerves. It is a rare disorder with a prevalence estimated at less than 1/100,000 in Western countries. Since the first description by Eugène Devic in 1894, the relationship between DNMO and multiple sclerosis (MS) has been controversial. Recent clinical, epidemiological, pathological and immunological data demonstrate that MS and DNMO are distinct entities. This distinction between DNMO and MS is crucial, as prognosis and treatment are indeed different. DNMO is now considered to be an autoimmune, antibody-mediated disease especially since the identification of a specific serum autoantibody, named NMO-IgG and directed against the main water channel of the CNS, aquaporin-4 (AQP4). The assessment of AQP4 antibodies (Abs) has initially been proposed to differentiate DNMO and MS. It has also enlarged the clinical spectrum of DNMO and proved to be helpful in predicting relapses and conversion to DNMO after a first episode of longitudinally extensive transverse myelitis or isolated optic neuritis. Lastly, the discovery of the pathogenic role of AQP4 Abs in DNMO leads to a better understanding of detailed DNMO immunopathology and the elaboration of relevant novel treatment strategies specific to DNMO. In this review, we summarize the present and future therapeutic implications generated by the discovery of the various pathogenic mechanisms of AQP4 Abs in DNMO pathophysiology.
MrSuccess wrote:Damage control ? What ever for ?
Listen up -
Professor Zamboni presented the world ..... with a significant new hypothesis ...... of the possible link of MS to a condition called CCSVI.
He published the results of his investigation of this possible link.
and ............ openly challenged any and all of his peers ...... to validate his findings ......... in their own way.
In plain words ..... " this is what I found ..... this is how I did it ..... can you do the same ? "
very simple ....... even an insect can understand the process..........
We've tossed around the term 'genius' and the possibility of a Nobel Prize .
Dr. Zamboni's work was preliminary and ground-breaking. Foundational.
cathyb wrote:What's the deal with these newest published studies. This is the second recent study where the researchers didn't find ANY problems at all with the MS group! Isn't not finding something 100% of the time just as unbelievable as finding something 100% of the time?
cathyb wrote:Are these researchers concluding that MS people, unlike the rest of the population, have NO problems at all? Maybe NOT having trouble with your blood flow is the problem related to MS.
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