ideal blood glucose levels for cerebral oxygenation

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

ideal blood glucose levels for cerebral oxygenation

Postby Cece » Mon Aug 01, 2011 3:28 pm

The arterial blood glucose concentration-dependent
cerebral uptake of glucose, as seen in the present study, suggests
that arterial blood glucose concentrations maintained
below the optimal Km of the endothelial GLUT1, that is less
than 8 mmol/l [13,44] will result in insufficient supply. This can
be overcome by maintaining arterial blood glucose levels at
about 8 mmol/l as reflected by increased metabolic stability.
This is in line with findings showing the impact of decreased
glucose supply on posttraumatic functional disturbances after
TBI in terms of induced CSD [20], increased extracellular
glutamate and elevated lactate/pyruvate ratio [19]. As pointed
out by Vespa and colleagues, cerebral oxygen consumption
was decreased in patients with higher blood glucose concentrations
(120 to 150 versus 90 to 120 mg/dl)
[19]. This is also
seen in the present patients. These findings strongly suggest
that activation of glucose transporter systems influence cerebral
oxygen consumption. As shown by Abate and colleagues
[48] increased cerebral glucose consumption is associated
with elevated OER, although low cerebral glucose consumption
results in decreased OER. Thus, the present data suggest
that metabolic instability, which can also occur independently
from cerebral ischaemia [2], can be influenced substantially by
changing arterial blood glucose levels.
... This is important because the ambient glucose levels within the neuronal environment is
rather low ranging from 1 to 2 mmol/l compared with normal
blood glucose levels between 5 and 6 mmol/l. Thus, any
decrease in arterial blood glucose in conjunction with impaired
endothelial glucose transport due to reduced GLUT1 expression
will endanger neuronal function and viability.
Conclusions Maintaining arterial blood glucose levels between
6 and 8 mmol/l appears superior compared with lower and
higher blood glucose concentrations in terms of stabilised
cerebral metabolism. It appears that arterial blood glucose
values below 6 and above 8 mmol/l should be avoided.
Prospective analysis is required to determine the optimal arterial
blood glucose target in patients suffering from severe TBI.

This was a study of patients with traumatic brain injury so it may not be universally applicable. But what we eat plays a role in how oxygenated our brains are. Moderate levels of glucose in the blood, neither too low nor too high, seems to be healthiest.

A cruel twist may be that we used our defective jugulars most at night, which is also when we have the long fast (thus leading us to break fast in the morning). There is less oxygen *and* less glucose overnight.
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Postby 1eye » Tue Aug 02, 2011 12:45 pm

And fewer dreams...

BTW I am concerned (no, not *that* one) about your use of TLAs. Usually, these are defined the first time they are used in a paper, but you quote glibly without passing on that info, so I get totally befuddled.

BTW - by the way
TLA - three-letter acronym
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
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Postby Cece » Tue Aug 02, 2011 1:27 pm

I am sorry YGB*. I will DBNT.*

I really like btw though.

* you get befuddled
* do better next time

REM sleep runs on glucose, there go the dreams....
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Postby Cece » Thu Aug 18, 2011 10:12 am

1eye wrote:BTW I am concerned (no, not *that* one)

perish the thought :D
about your use of TLAs. Usually, these are defined the first time they are used in a paper, but you quote glibly without passing on that info, so I get totally befuddled.

A friend posted this today on facebook, I was reminded of this conversation. :)

MIDDLE AGED TEXTING CODES:

ATD - at the doctor. BFF - best friend fell. BTW - bring the wheelchair. FWIW - forgot where I was. GHA - got heartburn again. IMHO - is my hearing aid on? OMMR - on my massage recliner. ROFLACGU - rolling on floor laughing and can't get up. TTYL - talk to you louder! Repost to share a laugh =)
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Postby munchkin » Thu Aug 18, 2011 2:42 pm

Those are too cute.
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