CCSVI Syndrome by Team ZAMBONI - Key Papers

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

CCSVI Syndrome by Team ZAMBONI - Key Papers

Postby MarkW » Tue Aug 09, 2011 3:22 pm

Here are three crucial papers which must be read for an overview of CCSVI syndrome.
MarkW

First - http://phleb.rsmjournals.com/cgi/reprint/25/6/269
Then - http://www.functionalneurology.it/commo ... 1ead753ee5
Next - http://www.ingentaconnect.com/content/m ... 8/art00006

========================================================
In this paper Prof Paolo Zamboni describes 'The CCSVI Syndrome'.

http://phleb.rsmjournals.com/cgi/reprint/25/6/269

I have started this as a new topic as there is much misleading information being quoted on CCSVI. If you post information which disagrees with this paper, be aware that I will challenge it if I spot it. My logic is simple - many people use this site for info on CCSVI and I want them to receive good info.

This paper is a clear statement of the syndrome found in pwMS and others. In academic environments a later paper on the same subject (CCSVI) replaces the authors' thinking as expressed in previous papers. P Zamboni and R Galeotti were the originators of the concept, so their definitions are the real ones. This is how medical science is developed.

For me this paper is absolutely crucial for everyone to read (using a medical dictionary as required).

MarkW
Last edited by MarkW on Thu May 23, 2013 1:54 pm, edited 18 times in total.
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Answer to www.thisisms.com/ftopict-17537.html

Postby MarkW » Tue Aug 09, 2011 3:30 pm

Hello Fiona (fee0001),
Prof Z's paper answers your questions in the thread: http://www.thisisms.com/ftopict-17537.html.
Yes it is heavy to read but it is the full story.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Postby thisisalex » Thu Aug 11, 2011 1:17 am

hey Mark,

I think Zamboni is still the best writer i have ever read :)

Why do you think this paper is critical?
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Re: CCSVI Syndrome - P Zamboni and R Galeotti

Postby CureOrBust » Thu Aug 11, 2011 5:24 am

MarkW wrote:In this paper Prof Paolo Zamboni describes 'The CCSVI Syndrome'.
http://phleb.rsmjournals.com/cgi/reprint/25/6/269


P Zamboni and R Galeotti wrote:For instance the prevalence in MS ranges between 56% and 100%, indicating that CCSVI is one of the major risk factors for the development of MS.
I think I must of miss the paper, and it wasn't referenced, that proved CCSVI wasn't a syndrome caused by MS?

PS be gentle, I have my third CCSVI treatment scheduled in the next two weeks, and it involves flying to the US for an IVUS :peace: I swear, I do not hang around under bridges :wink:
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Use of English

Postby MarkW » Fri Aug 12, 2011 7:51 pm

Hello thisisalex,

I used this meaning of critical:
From Oxford English Dictionary - Critical =
"having a decisive or crucial importance in the success or failure of something: eg temperature is a critical factor in successful fruit storage"

I will try not to use non standard meanings in future.
I meant - This paper is crucial to understand Prof Zamboni's ideas.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Syndrome or Cause

Postby MarkW » Fri Aug 12, 2011 8:01 pm

Hello CureOrBust,

When you have less important things on your mind, have a look at the meaning of syndrome. Hint it is a collection of symptoms.
Also CCSVI is important in the development or progression of MS but this does not imply that it is a cause of MS.

Best wishes for your trip (to NY ?), mine (procedure 2) went well.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Why no comments ?????

Postby MarkW » Fri Aug 19, 2011 9:22 am

I am concerned that people researching CCSVI are not reading this paper and commenting on it.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Postby MegansMom » Tue Aug 23, 2011 6:44 am

Bumping this post up...

It should be a sticky
Cat (Catherine Somerville on FB)
MegansMom
My 35 yo daughter is newly dx 8/19/10 (had 12 symptoms)
Dx with Type A CCSVI- 1 IJV & double "candy wrapper" appearance of her Azygos
Venoplasty done Sept 21, 2010
Doing extremely well-
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Postby Cece » Tue Aug 23, 2011 9:30 am

Abstract

Chronic cerebrospinal venous insufficiency (CCSVI) is a syndrome characterized by stenosies
of the internal jugular and/or azygous veins (IJVs-AZ) with opening of collaterals and
insufficient drainage proved by reduced cerebral blood flow and increased mean transit
time in cerebral MRI perfusional study.
The present review is aimed to give a
comprehensive overview of the actual status of the art of the diagnosis and treatment of
this condition. As far as the origin of venous narrowing is concerned, phlebographic
studies of the IJVs and AZ systems demonstrated that venous stenoses were likely to be
truncular venous malformations; mostly, they are intraluminal defects such as malformed
valve, septa webs. CCSVI condition has been found to be strongly associated with
multiple sclerosis (MS), a disabling neurodegenerative and demyelinating disease
considered autoimmune in nature. In several epidemiological observations performed at
different latitudes on patients with different genetic backgrounds, the prevalence of CCSVI
in MS ranges from 56% to 100%. To the contrary, by using venous MR and/or different
Doppler protocols, CCSVI was not detected with the same prevalence. Two pilot studies
demonstrated the safety and feasibility in Day Surgery of the endovascular treatment of
CCSVI by means of balloon angioplasty (PTA). It determines a significant reduction of
postoperative venous pressure. Restenosis rate was found out elevated in the IJVs, but
negligible in the AZ. However, PTA seems to positively influence clinical and QoL
parameters of the associated MS and warrants further randomized control trials.

There is Dr. Zamboni's definition of CCSVI as a syndrome.
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Key paper

Postby MarkW » Thu Sep 01, 2011 1:39 pm

bump.............MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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A Syndrome is

Postby MarkW » Sat Sep 03, 2011 6:10 am

A syndrome is (merriam-webster dictionary):
- a group of signs and symptoms that occur together and characterize a particular abnormality or condition.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Postby Thekla » Sat Sep 03, 2011 2:00 pm

the part about the latitude study....did he find any correlation in the incidence of ccsvi and latitude?


... "In several epidemiological observations performed at different latitudes on patients with different genetic backgrounds, the prevalence of CCSVI in MS ranges from 56% to 100%. To the contrary, by using venous MR and/or different Doppler protocols, CCSVI was not detected with the same prevalence."
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Lattitude and CCSVI Syndrome

Postby MarkW » Thu Sep 08, 2011 7:54 am

There is no data on lattitude and CCSVI at present. It will be difficult to analyse as ethnicity, genetic make up, and sun exposure all need to be accounted for in any study.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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CCSVI Syndrome is about stenosis and reduced flow

Postby MarkW » Sun Sep 11, 2011 3:19 am

Prof Zamboni says that CCSVI Syndrome is about stenosis and reduced flow. Treating a syndrome is about treat the symptoms that are indentified. Please do not get distracted by the thread:
chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic17842.html
It is an interesting intellectual debate but there is not sufficient data to be sure (in my rarely humble opinion).
Please just have your CCSVI symptoms diagnosed and treated.

MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Re: KEY INFO: CCSVI Syndrome - P Zamboni and R Galeotti

Postby MarkW » Thu Sep 15, 2011 1:00 am

Making sure this stays on page one...............MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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