The study being refered to was an international genetics study on over 9,000 MSers and over 17,000 controls. The evidence for MS being automine related has been solidified by the fact that the 29 genetic markers were related to T cell proliferation, lyphocytes, cytokines, and other immune responses.
This only solidifies the case that the immune system plays a role in MS. In CCSVI theory, the immune system has a role to play.
Unfortunately for ccsvi, it has very little to go by other than the testamonials presented by patients.
There is a lot of research underway on endovascular treatment. The science is coming if not already here.
The science is new for ccsvi, and doctors are still debating if it is a natural variation, if it exists, or if it may be related to dehydration or extended immobility.
Extended immobility was not a factor in my case and my CCSVI was severe (80% and 99% bilateral jugular stenosis). Dehydration is more of a potential factor if we are looking at narrowing of the veins, not of the valve. Valve malformations in the jugular are the most common presentation of CCSVI according to clinical reports.
No clinical trials on the surgery, because the parameters for it have not been laid proper.
The Canadian government is funding clinical trials of endovascular treatment. Dr. Dake has a fully funded trial ready to go once he can get past the hold-up. Dr. Siskin and Dr. Mehta separately have trials underway as does BNAC. Dr. Simka and Dr. Ludgya have published data as well. I am sure I am forgetting some. Dr. Ponec presented on his registry results at the AAC symposium, that was interesting.
I don't know if ccsvi causes any symptoms that can be relieved from the surgeries. So far, it is pretty vague and not leaning in that direction.
At ISNVD, the data presented showed a consensus that CCSVI treatment alleviated MS fatigue. MS fatigue is the most common MS symptom and it is not well explained nor does it have any treatment that particularly works.