Rush University--blocked blood vessels and aging

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Rush University--blocked blood vessels and aging

Postby cheerleader » Thu Sep 01, 2011 3:29 pm

Dr. Aron Buchman is a neurologist at Rush University in Chicago. For the past 20 years, he has been studying the aging brain and subtle changes that come before Alzheimers and Parkinsons diagnoses. Here is the press regarding his most recent study, which looks at the brains after the participants have passed---

http://www.eurekalert.org/pub_releases/ ... 082911.php

Signs of aging may be linked to undetected blocked brain blood vessels

Many common signs of aging, such as shaking hands, stooped posture and walking slower, may be due to tiny blocked vessels in the brain that can't be detected by current technology.

In a study reported in Stroke: Journal of the American Heart Association, researchers from Rush University Medical Center, Chicago, examined brain autopsies of older people and found:
Microscopic lesions or infarcts — too small to be detected using brain imaging — were in 30 percent of the brains of people who had no diagnosed brain disease or stroke.
Those who had the most trouble walking had multiple brain lesions. Two-thirds of the people had at least one blood vessel abnormality, suggesting a possible link between the blocked vessels and the familiar signs of aging.

"This is very surprising," said Dr. Aron S. Buchman, lead author of the study and associate professor of neurological sciences at Rush. "The public health implications are significant because we are not identifying the 30 percent who have undiagnosed small vessel disease that is not picked up by current technology. We need additional tools in order to identify this population."

In 1994, the researchers began conducting annual exams of 1,100 older nuns and priests for signs of aging. The participants also donated their brains for examination after death. This study provides results on the first 418 brain autopsies (61 percent women, average 88 years old at death).
Although Parkinson's disease occurs in only 5 percent of older people, at least half of people 85 and older have mild symptoms associated with the disease.
Before the study, researchers believed that something more common, such as microscopic blocked vessels, might be causing the physical decline. The study's autopsies found the small lesions could only be seen under a microscope after participants died. The lesions couldn't be detected by current scans.
During the annual exams of the nuns and priests, researchers used the motor skills portion of a Parkinson's disease survey to assess their physical abilities. Researchers observed and rated the participants'
Balance, Ability to maintain posture, Walking speed, Ability to get in and out of chairs, Ability to make turns when walking, Sense of dizziness.

"Often the mild motor symptoms are considered an expected part of aging," said Buchman, who is also a member of the Rush Alzheimer's Disease Center. "We should not accept this as normal aging. We should try to fix it and understand it. If there is an underlying cause, we can intervene and perhaps lessen the impact."


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How does this relate to CCSVI?

One important similarity is microvascular brain abnormalities in both the elderly and pwMS. Just as Rindfleisch noted microscopic engorged vessels inside MS lesions in the brains of deceased MS patients, the Rush doctors note blocked vessels and microscopic lesions in the brains of the elderly with "mild motor symptoms." From 1863 and Rindfleisch to 2011 and Rush University....our technology notes these microscopic vascular changes in the brain after death.

Thanks to new technology, microvascular abnormalities have been found in vivo (meaning, in living pwMS) using the new, higher powered 7Tesla MRI machines. I hope the Rush researchers might utilize 7Tesla technology, to see if these vascular changes in the elderly are detectable. Because they are in MS:

Seven-Tesla magnetic resonance imaging: new vision of microvascular abnormalities in multiple sclerosis.

We demonstrated markedly enhanced detection of unique microvascular involvement associated with most of the visualized MS lesions with abnormal signals on and around the venous wall on 7-T compared with 3-T MRI.

These findings, which have never been shown on conventional fields of MRI, not only allow for direct evidence of vascular pathogenesis in MS in vivo but also have important implications for monitoring lesion activity and therapeutic response.

http://www.ncbi.nlm.nih.gov/pubmed/18541803



cheer
ps --where's Cece??
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby munchkin » Thu Sep 01, 2011 7:42 pm

Sorry for the rant.

This is very interesting data.
Last edited by munchkin on Fri Sep 02, 2011 4:42 am, edited 1 time in total.
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Postby HappyPoet » Thu Sep 01, 2011 9:12 pm

Finally, I know the correct answer to a question!
Cece is with her family at Disney World in Florida for the week. :)
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Postby cheerleader » Thu Sep 01, 2011 9:43 pm

HappyPoet wrote:Finally, I know the correct answer to a question!
Cece is with her family at Disney World in Florida for the week. :)

Thanks, HP!! Glad to know she's getting a vacation, and I think you've been correct on many topics :)
munchkin, I'm sorry you've had it so rough. You have every right to vent, and then some. I wish this were easier, and I wish everyone had local doctors who could follow them and treat them w/ a standardized protocol, but we're not there yet. And we need more research. I hope that the wonderful researchers at the International Society of Neurovascular Disease will get in touch w/the Rush neurologists and continue to look at microvascular abnormalities in pwMS.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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