You could also maybe try bromelain, pineapple supplement, which does the exact same thing to leukocytes and is not vasoconstricting.
I was telling blossom just last night that she should ask her doctor about bromelain.
Studies comparing Daflon and bromelain to see how the compounds affect the annulus would be interesting and helpful because one compound might be better than the other compound regarding effects on the annulus--one compound might work faster, and/or have a more robust effect, and/or create stronger permeability defenses,
etc., than the other compound.
I still can't find any studies on bromelain and the annulus, but with my poor searching skills, that result doesn't mean there aren't any such studies which is why I asked earlier (page one):
cheer, do you know if your recommended supplements, bromelain and quercetin, decrease valvular remodeling and reflux? Thank you!
If it's a given that Daflon and bromelain do 'the exact same thing' to leukocytes, it would be great if we could then assume that Daflon and bromelain do 'the exact same thing' to the annulus, but we can't really make that assumption, or can we? In addition to Daflon's effect on leukocytes, knowing if Daflon has other important actions that might account for its effect on the annulus would be good to know.
Bromelain might or might not affect the annulus in (all) the same way(s) that Daflon did in the UCSD study. We just don't know. We might never find, retrospectively nor prospectively, all the answers to all our questions, but we might learn much along the way.
Edit is in red