Daflon 500mg tracking thread

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: Daflon 500mg tracking thread

Postby MrSuccess » Fri Sep 16, 2011 8:19 pm

I'd drink a dog shit cocktail .... if it aided the cause...


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Re: Daflon 500mg tracking thread

Postby Ruthless67 » Fri Sep 16, 2011 9:26 pm

I purchased Lifetime brand Diosmin complex and just started taking it. 2 a day with food. I have a 30 day supply and I'll post what I notice. $10.04 at Vitacost for 60 capsules

So earlier tonight I was doing some research on how Tysabri works and how Diosmin work and it really is interesting. Here is one link I found on how Tysabri works.
http://www.drugdevelopment-technology.c ... /antegren/
By binding to alpha-4 integrin receptor sites, Tysabri selectively blocks leukocyte adhesion to blood vessel walls and subsequent migration of these immune cells to sites of chronic inflammation, where they can exacerbate the inflammatory process. Leukocytes are believed to mediate the damage to the protective myelin sheath of nerve cells seen in multiple sclerosis.


Then there is a link to a PDF research paper on Diosmin & rats,
http://www.bmj.sk/2011/11210-02.pdf
There is an interesting description of how Diosmin works in the 2nd to last paragraph on page one but I don’t know how to copy it.

I’m not as medically suave as many of you, (Probably could be considered illiterate on that score, lol.) but it seems like they do the same thing with the blocking of Leukocyte adhesion to blood vessel walls. Can any of you enlighten me further? There is even a hotmail address to one of the researchers at the top of the PDF.

Are any of you old enough to remember a movie where money was thrown into a huge "pool" of sewage and people jumped into it to retrieve the $$? :lol: I don't remember the title, but I'm thinking it was a Beatle's clip???. But I'm definately willing to jump in and try Diosmin. :wink:

Lora

Oh yeah, I also ran across this little ditty from the MS Society regarding Tysabri.
http://www.nationalmssociety.org/news/n ... x?nid=2308
Updated August 22, 2011
According to information released by Biogen Idec, as of August 4, 2011 there have been 150 confirmed cases of progressive multifocal leukoencephalopathy (PML, a viral infection of the brain that usually leads to death or severe disability) among people who have used Tysabri® (natalizumab, Biogen Idec and Elan Pharmaceuticals) after it became available for prescription in July 2006. Of the cases, 85 occurred in Europe, 58 occurred in the United States, and 7 occurred in the rest of the world. As of June 30, 2011, approximately 88,100 people worldwide have used Tysabri since it was marketed.
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Re: Daflon 500mg tracking thread

Postby mtf » Sat Sep 17, 2011 7:34 am

I love dogs, but I prefer to try Daflon instead of dog shit...at least for now.
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Re: Daflon 500mg tracking thread

Postby dania » Sat Sep 17, 2011 9:27 am

Boy!!!!!!!!!!!!!!!!!! did this thread get hijacked! But it is funny as to what we would do to get better.
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Re: Daflon 500mg tracking thread

Postby Jugular » Sat Sep 17, 2011 4:35 pm

Yeah. How about you people on dog shit start you're own tracking thread. [With drop foot, it's aggravating enough for me just stepping in it]

:)

Back on topic - the first day of taking my hands felt warm (especially my bad one) and I had some lightheadedness - but that only lasted a day. After three, I haven't much to report. Maybe a bit better, but nothing outside the range that I got after liberation. I think any improvements will take a while.
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Re: Daflon 500mg tracking thread

Postby David1949 » Sun Sep 18, 2011 10:45 am

I've been one who thinks that Daflon might offer some help for CCSVI. But I'm not sure it's a good idea to buy the stuff over the internet and try it out on yourself. I hope you will be very careful about this or maybe not do it at all until more is known about it. At least we should find out how Ginger is doing on it.

I know all of us want to be free of this MS monster, but I don't think we should throw caution to the wind.
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Re: Daflon 500mg tracking thread

Postby Jugular » Sun Sep 18, 2011 1:50 pm

David1949 wrote:I've been one who thinks that Daflon might offer some help for CCSVI. But I'm not sure it's a good idea to buy the stuff over the internet and try it out on yourself. I hope you will be very careful about this or maybe not do it at all until more is known about it. At least we should find out how Ginger is doing on it.

I know all of us want to be free of this MS monster, but I don't think we should throw caution to the wind.

Agreed. There are some counterpoints to keep in mind though. Daflon is considered to be a supplement rather than a drug which is why it can be ordered without prescription. In several randomized double-blind placebo-controlled trials, it was found to have very few negative side effects and no known interactions. In one study, patients taking the placebo had a higher dropout rate. Here is a study on it's safety.

Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease.
Meyer OC.
Source
Service de Rhumatologie, Hôpital Bichat, Paris, France.
Abstract
Daflon 500 mg is a new flavonoid vasoprotector venotonic agent whose active principle is micronized and contains 90% diosmin and 10% flavonoids expressed as hesperidin. In animal studies, the safety of Daflon 500 mg is shown by an LD50 (lethal dose 50) of more than 3 g/kg, ie, 180 times the daily therapeutic dose, as well as by the absence of any toxic effect after repeated oral dosing for thirteen and twenty-six weeks, using a dose representing 35 times the daily dosage, in the rate and primate. Daflon 500 mg has no mutagenic action nor any significant effect on reproductive function. Gastrointestinal tolerance is good when administered orally in the rat. Transplacental passage and passage into breast milk are minimal. In the rat, 0.003% of the administered dose has been found in each fetus and 1% in breast milk. Clinical trials fulfill international scientific requirements and have collected more than 2850 patients treated with Daflon 500 mg at the dosage of two tablets per day for six weeks to one year. The proportion of patients with side effects (10% of those treated), essentially of a gastrointestinal or autonomic nature and leading to a rate of only 1.1% trial dropouts, is less than described in 225 patients given a placebo (13.9%) in controlled trials. Satisfactory clinical acceptability already confirmed in the short term was equally found in long-term treatment. Hemodynamic parameters (systolic and diastolic blood pressure) as well as laboratory parameters (hematology, liver and renal function, metabolic) were uninfluenced even by prolonged treatment for one year at the dosage of two tablets per day.


Taking it for CCSVI (as opposed to MS) is an admittedly new experimental use, but it's efficacy and safety to treat CVI has been well-established. I think, compared to traveling to a foreign country to have one's veins roto-routed, it would seem to me to be fairly low on the reckless scale. But then again, read my warning at the start of the thread.
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Re: Daflon 500mg tracking thread

Postby leetz » Sun Sep 18, 2011 1:56 pm

Dog Shit??? I would, eat, drink, make a shake, bathe, sleep, and powder my nose with it if it would cure me...lol!
GOD BLESS.... CCSVI treatment Dr. Siskin great doc....symptom's improved for about 3 week's (gait, balance, spasticity) now back to square 1...
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Re: Daflon 500mg tracking thread

Postby Cece » Sun Sep 18, 2011 2:15 pm

Thanks for that study, I hadn't seen that one.
I found it interesting that the doctors in Bulgaria prescribed six months of Daflon after ccsvi venoplasty. They had reason to think it might be of use to those patients.
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Re: Daflon 500mg tracking thread

Postby Chicagoboy23 » Sun Sep 18, 2011 8:44 pm

Check out ebay.....
Daflon 500 has a wide range of prices starting from 19.95 for a box.
Also, here is a link for Daflon effects for venous circulatory problems.

Take a look.

Please report any positive or negative results.

Peace..

Mark
http://www.youtube.com/watch?v=iugFL21Z-xg
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Re: Daflon 500mg tracking thread

Postby Rosegirl » Mon Sep 19, 2011 5:22 am

What kind of dog do you prescribe? I imagine great dane would be a stronger dose than one of those little yappy dogs that women in Hollywood carry in their purses, although it might be easier to administer. . .

I've tried for days not to send this. Sorry, I just couldn't help myself. . . :lol:
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Re: Daflon 500mg tracking thread

Postby Ruthless67 » Mon Sep 19, 2011 8:28 am

Hi All,
It's been 3 days since I started the Diosmin and like all things MS it's sometimes hard to tell what is going on. I have two vericose vein areas on my left calf, and they don't appear to have changed any. My legs still feel heavy and "numbish" like usual, but my feet are warmer, and sometimes they and my numb hands feel alittle tingly. So I'll continue with the 30 day supply.

Lora
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Re: Daflon 500mg tracking thread

Postby David1949 » Mon Sep 19, 2011 9:52 am

" I think, compared to traveling to a foreign country to have one's veins roto-routed, it would seem to me to be fairly low on the reckless scale. "

Well I guess if liberation is like having one's veins roto-routed then Daflon is akin to pouring Draino into the veins. :smile:

I am somewhat concerned by Blossom's post which indicates that Tysabri works in somewhat the same manner as Daflon, by keeping the leukocytes from sticking to the vein walls. We all know what Tysabri can do. :cry:
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Re: Daflon 500mg tracking thread

Postby David1949 » Mon Sep 19, 2011 9:57 am

OOPs sorry it wasn't Blossom's post about Tysabri it was Ruthless' post. (Post editor is not working right now)
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Re: Daflon 500mg tracking thread

Postby IHateMS » Mon Sep 19, 2011 2:59 pm

Ruthless67 wrote:Hi All,
It's been 3 days since I started the Diosmin and like all things MS it's sometimes hard to tell what is going on. I have two vericose vein areas on my left calf, and they don't appear to have changed any. My legs still feel heavy and "numbish" like usual, but my feet are warmer, and sometimes they and my numb hands feel alittle tingly. So I'll continue with the 30 day supply.

Lora


are you adding the 10% HESPERIDIN??? since daflon is 90% diosmin and 10 hesperidin
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