Daflon 500mg tracking thread

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Re: Daflon 500mg tracking thread

Postby HappyPoet » Thu Sep 29, 2011 6:38 pm

Daflon:

Dosing & Route of administration
ORAL
- Two tablets per day: 1 tablet at noon and 1 tablet in the evening.
- Hemorrhoidal Crisis: 6 tablets per day for 4 days, then 4 tablets per day for 3 days.

The innovation with Daflon 500 consists of the micronization of its active constituent from particles of 30-80 microns to particles of <2 microns. This new and optimized form allows Daflon 500 to increase venous tone from the first 2-tab dose by the 1st hour and provides Daflon 500 with added clinical efficacy.

Actions:
*Daflon 500 is a phlebotonic drug and a vascular protecting agent. The efficacy of Daflon 500 is accounted for by its specific action on the principal elements of venous disease. Daflon 500 is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaiine. Thus, Daflon 500 decreases venous capacitance, venous distensibility and venous emptying time.

*Daflon 500 protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Daflon 500 normalizes capillary permeability and strengthens capillary resistance.

*Daflon 500 acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Daflon 500 on CVI-associated edema.

Double-blind, placebo-controlled studies have demonstrated Daflon 500's efficacy on chronic venous insufficiency. Daflon 500 significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment, nocturnal cramps and restless legs. In addition to conventional compression therapy, Daflon 500 has also demonstrated to cure 3 times as many venous leg ulcers as placebo and to accelerate their complete healing.

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Re: Daflon 500mg tracking thread

Postby blossom » Thu Sep 29, 2011 9:33 pm

anyone know if a person has high blood pressure if there would be a problem with useing daflon? i have mthfr also "geneticaly prone for heart attack, stroke and clots."
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Re: Daflon 500mg tracking thread

Postby dania » Thu Sep 29, 2011 10:04 pm

http://cpt.sagepub.com/content/7/3/139.abstract

DOSAGE IN THIS STUDY 3-500mg every 8 hours

Methods: A group of 90 patients with severe venous hypertension due to chronic venous insufficiency, ankle swelling, and lipodermatosclerosis were included. After informed consent, patients were randomized into a Venoruton and a Daflon (DF) group: patients in the Venoruton group received oral HR (2 g/day for 8 weeks); those in the Daflon group received three 500-mg tablets daily every 8 hours. The two groups were comparable for age and sex distribution. The mean age was 41 years (SD ± 11) in the Venoruton group (46 patients) and 41.3 (SD ± 12) in the DF group (44 patients).
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Re: Daflon 500mg tracking thread

Postby PointsNorth » Thu Sep 29, 2011 10:35 pm

dania wrote:http://cpt.sagepub.com/content/7/3/139.abstract

DOSAGE IN THIS STUDY 3-500mg every 8 hours

Methods: A group of 90 patients with severe venous hypertension due to chronic venous insufficiency, ankle swelling, and lipodermatosclerosis were included. After informed consent, patients were randomized into a Venoruton and a Daflon (DF) group: patients in the Venoruton group received oral HR (2 g/day for 8 weeks); those in the Daflon group received three 500-mg tablets daily every 8 hours. The two groups were comparable for age and sex distribution. The mean age was 41 years (SD ± 11) in the Venoruton group (46 patients) and 41.3 (SD ± 12) in the DF group (44 patients).


Given this study, would using Venoruton instead of Daflon be an option?? It looks to be available online
http://www.mailrxmeds.com/online/drugs/Venoruton.shtml

best, PN
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Re: Daflon 500mg tracking thread

Postby Jugular » Thu Sep 29, 2011 10:47 pm

blossom wrote:anyone know if a person has high blood pressure if there would be a problem with useing daflon? i have mthfr also "geneticaly prone for heart attack, stroke and clots."

This sounds like an excellent question for your doctor.
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Re: Daflon 500mg tracking thread

Postby David1949 » Fri Sep 30, 2011 9:36 pm

Daflon arrived today. Will take two a day and see what happens.
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Re: Daflon 500mg tracking thread

Postby David1949 » Fri Sep 30, 2011 9:52 pm

A few days ago I sent an email to the makers of Daflon asking if they had done any testing on Daflon with regards to CCSVI. They sent me this very nice reply:

"Dear Sir,

I thank you very much for the interest you have for our product, as this was related to us by our Uruguayan colleagues.

Unfortunately we do not have any experience with Daflon 500 in cerebrospinal insufficiency and are not able to answer your question.

However we understand why you were interested in such an indication since you probably refer to the still controversial theory that multiple sclerosis and cerebrospinal insufficiency might have an origin based on cerebral venous insufficiency. Nevertheless, we cannot give you any opinion or indication about such application and therefore, ethically speaking, we will not recommend the use of Daflon 500 mg in such a so specific pathology."
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Re: Daflon 500mg tracking thread

Postby Jugular » Sat Oct 01, 2011 2:07 am

You should write back to thank them, but explain that you are not looking for their advice just that this may be another use for their drug that they should look into. Market potential = $1 Billion per year. The clinical trial would be so simple. No need to bother with imaging studies or sham surgery. Just start with a small placebo-controlled study measuring QOL and go from there.
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Re: Daflon 500mg tracking thread

Postby HappyPoet » Sat Oct 01, 2011 6:12 am

Hi PointsNorth,

I'm not sure what to think about Venoruton vs Daflon. So, for the time being, I'm going to try Daflon because of the animal study by Dr. Bergan et al that showed Daflon reduced adhesion molecules and leukocytes and reduced valvular remodeling.

Regarding remodeling: I forget in which thread this was discussed, but Cece made a comment about if remodeling is what I think it is (or something similar). In all my research, valvular remodeling in veins (and arteries) refers to pathological changes, mostly due to effects of inflammation: stiffening of leaflets, overgrowth of cusps and leaflets, and shortening of the annulus.
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Re: Daflon 500mg tracking thread

Postby PointsNorth » Sat Oct 01, 2011 9:53 am

Thanks HP,

I will look at Purchasing some. I think I read on Daflon website that it takes 1-2 months to see results so I look forward to updates on this thread in the coming weeks!

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Re: Daflon 500mg tracking thread

Postby ErikaSlovakia » Sat Oct 01, 2011 10:03 am

PointsNorth wrote:Thanks HP,

I will look at Purchasing some. I think I read on Daflon website that it takes 1-2 months to see results so I look forward to updates on this thread in the coming weeks!

PN

I was on Daflon exactly 60 days - March and April 2011 (2x a day). I felt absolutely nothing so I stopped. It was original from the Pharmacy. I paid one part and my Health Insurance Company paid for the second part.
But maybe it helps some patients. I do not know...
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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Re: Daflon 500mg tracking thread

Postby Jugular » Sat Oct 01, 2011 10:26 am

ErikaSlovakia wrote:
PointsNorth wrote:Thanks HP,

I will look at Purchasing some. I think I read on Daflon website that it takes 1-2 months to see results so I look forward to updates on this thread in the coming weeks!

PN

I was on Daflon exactly 60 days - March and April 2011 (2x a day). I felt absolutely nothing so I stopped. It was original from the Pharmacy. I paid one part and my Health Insurance Company paid for the second part.
But maybe it helps some patients. I do not know...
Erika
Why were you on it?
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Re: Daflon 500mg tracking thread

Postby David1949 » Sat Oct 01, 2011 11:27 am

Jugular wrote:You should write back to thank them, but explain that you are not looking for their advice just that this may be another use for their drug that they should look into. Market potential = $1 Billion per year. The clinical trial would be so simple. No need to bother with imaging studies or sham surgery. Just start with a small placebo-controlled study measuring QOL and go from there.


If the informal study at this thread shows promise I'll do that.
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Re: Daflon 500mg tracking thread

Postby ErikaSlovakia » Sun Oct 02, 2011 1:24 am

Jugular wrote:
ErikaSlovakia wrote:
PointsNorth wrote:Thanks HP,

I will look at Purchasing some. I think I read on Daflon website that it takes 1-2 months to see results so I look forward to updates on this thread in the coming weeks!

PN

I was on Daflon exactly 60 days - March and April 2011 (2x a day). I felt absolutely nothing so I stopped. It was original from the Pharmacy. I paid one part and my Health Insurance Company paid for the second part.
But maybe it helps some patients. I do not know...
Erika
Why were you on it?

Because of CCSVI.
Erika
Aug. 7, 09 Doppler Ultras. in Poland, left Jugul. valve problem, RRMS since 1996, now SPMS,
- Nov.3,09: one stent in the left jug. vein in Katowice, Poland, LDN, never on DMDs
- Jan. 19, 11: control venography in Katowice - negative but I feel worse
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Re: Daflon 500mg tracking thread

Postby Thekla » Sun Oct 02, 2011 2:09 pm

It requires a prescription here, although the article from the pharmacy also mentioned eating a low-fat diet and avoiding pork to help. I'd like to try it but it will be a while.
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