I have read that inflammation causes venous anamolies through Venous Growth Factor. It is created as a repair operation in the body. Are the venous anomolies noted by ccsvi not supposed to be caused by inflamation? Does that make them genetic anamolies? Do any other venous disease show organ specific immune responses?
The types of anomolies created by inflammation would be stenosis and thrombosis. What the researchers are finding in CCSVI are truncular malformations, formed in uetero. These include inverted valves, malformed valves, webs, atresia (missing veins) and hypoplasia (unformed or small veins)
Here's a paper on the differentiation, written by a vascular expert, which shows these same malformations in Budd Chiari diseasehttp://fondazionehilarescere.org/pdf/03-2518-ANGY.pdf
The response of the liver in Budd Chiari disease is different, because there is not a blood brain barrier in the liver, and the immune system is not kept out, as it is in the brain and spine....so the appearance of an "auto immune" reaction won't be found in other organs. However, there is an immune activation and fibrin cuffs found in venous ulcers of the legs, when flow is impeded by damaged valves, which is what started Dr. Zamboni on this exploration of venous disease and MS.http://jrsm.rsmjournals.com/content/99/11/589.full
hope this helps!
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS