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Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

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CureOrBust
 Post subject: Curcumin Chelates Iron
PostPosted: Mon Oct 24, 2011 3:46 am 
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I could not find a recent Iron chelation thread, and do not remember ever hearing about curcumin and iron before.

But while looking up different forms of curcumin, I stumbled across a warning that it chelates iron from the body. I did a quick search in Google and the links were endless. Here is a single simple one that I stumbled across, which peaked my interest initially.

Iron chelation in the biological activity of curcumin. I'm sure its not the best, but its at least one example. And the full article appears to be HERE.
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Cece
PostPosted: Mon Oct 24, 2011 9:02 am 
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Does it cross the blood brain barrier?

I have a bottle of curcumin supplements, although I am not taking them regularly. It was on Cheer's endothelial health program.
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cheerleader
PostPosted: Mon Oct 24, 2011 9:21 am 
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Cece wrote:
Does it cross the blood brain barrier?

I have a bottle of curcumin supplements, although I am not taking them regularly. It was on Cheer's endothelial health program.


Curcumin/tumeric has been shown to cross the BBB when injected, but not when taken orally. I recommend it for it's antioxidant and inflammatory reducing properties, which have been proven in clinical trails. Jeff takes 500 mg. a day and we eat alot of Indian food.
I like EGCG for chelating properties a bit more....it crosses the BBB when taken orally, and is being studied in MS at Charité
https://www.facebook.com/notes/ccsvi-in ... 3333122210

Here's more info on curcumin.
http://lpi.oregonstate.edu/infocenter/p ... /curcumin/

cheer

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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS


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CureOrBust
PostPosted: Tue Oct 25, 2011 5:47 am 
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cheerleader wrote:
Curcumin/tumeric has been shown to cross the BBB when injected, but not when taken orally.
Yes it has. :?

Curcumin blocks brain tumor formation
Quote:
.... Oral delivery of this food component has been less effective because of its low solubility in water. We show that a soluble formulation of curcumin crosses the blood–brain barrier but does not suppress normal brain cell viability. ...

Oral Curcumin Mitigates the Clinical and Neuropathologic Phenotype of the Trembler-J Mouse: A Potential Therapy for Inherited Neuropathy
Quote:
...Analysis of curcumin bioavailability (table 1) has also shown the presence of curcumin in brain within 2 h after treatment (with 100 mg of curcumin per kg of body weight) in both pups and adults tested in our study, suggesting that it might cross the blood-brain barrier and reach the brain in treated mice....
OK, so that ones a "might"... But they found it in the mice brains. Not many volunteers for human trials ending in disection.

The effect of curcumin (turmeric) on Alzheimer's disease: An overview
Quote:
Oral bioavailability:
Curcumin has poor bioavailability. Because curcumin readily conjugated in the intestine and liver to form curcumin glucuronides.[39] In a clinical trial conducted in Taiwan, serum curcumin concentrations peaked one to two hours after an oral dose. Peak serum concentrations were 0.5, 0.6 and 1.8 micromoles/L at doses of 4, 6 and 8 g/day respectively.[40] It is also measured in urine at a dose of 3.6 g/day. Absorption is poor following ingestion in mice and rats. 38% to 75% of an ingested dose of curcumin is excreted in the feces. Absorption appears to be better with food. Curcumin crosses the blood brain barrier and is detected in CSF.


Curcumin does have a bioavailability issue. I would not take it solely for its Iron chelation properties. It was simply an interesting side fact I came across while I was looking into more bioavailable forms, which I had never heard of before.
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gibbledygook
PostPosted: Sun Oct 30, 2011 2:26 am 
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Also our blood brain barrier is badly compromised so maybe more curcumin gets through! I have taken large amounts of curcumin in the past and noticed a positive effect and I'd be taking it every day if I weren't pregnant.

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3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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Cece
PostPosted: Sun Oct 30, 2011 11:10 am 
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Great information on curcumin. I checked the expiration on mine and it's a month away so I will be taking lots of curcumin in the next few weeks. :)
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Thekla
PostPosted: Wed Nov 02, 2011 2:32 pm 
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I like the bit 'absorption appears better with food'. I cook a lot with turmeric---my kids think rice is supposed to be yellow. I read years ago that it was supposed to be good for something and just started using it--we buy big bags! I've taken it as a supplement too but I much prefer to eat and drink my nutrients. Maybe it isn't as concentrated but if it is absorbed better, perhaps lower concentrations frequently works.
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daniel
PostPosted: Wed Nov 02, 2011 7:41 pm 
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Thekla -- that's my strategy too. I know lots of things in nature have a synergetic effect (eg. combining two items will produce 10x of the benefit of taking both items individually)... though there aren't many studies on this. I try and put spices in everything I can. Cinnamon in coffee in the morning or on apples. Turmeric,cayenne sprinkled in foods, etc. Also curry powder as well as mustard are great sources of turmeric.
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Board index » Treatments » Chronic Cerebrospinal Venous Insufficiency (CCSVI)

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