Cece wrote:Does it cross the blood brain barrier?
I have a bottle of curcumin supplements, although I am not taking them regularly. It was on Cheer's endothelial health program.
Yes it has.cheerleader wrote:Curcumin/tumeric has been shown to cross the BBB when injected, but not when taken orally.
.... Oral delivery of this food component has been less effective because of its low solubility in water. We show that a soluble formulation of curcumin crosses the blood–brain barrier but does not suppress normal brain cell viability. ...
OK, so that ones a "might"... But they found it in the mice brains. Not many volunteers for human trials ending in disection....Analysis of curcumin bioavailability (table 1) has also shown the presence of curcumin in brain within 2 h after treatment (with 100 mg of curcumin per kg of body weight) in both pups and adults tested in our study, suggesting that it might cross the blood-brain barrier and reach the brain in treated mice....
Curcumin has poor bioavailability. Because curcumin readily conjugated in the intestine and liver to form curcumin glucuronides. In a clinical trial conducted in Taiwan, serum curcumin concentrations peaked one to two hours after an oral dose. Peak serum concentrations were 0.5, 0.6 and 1.8 micromoles/L at doses of 4, 6 and 8 g/day respectively. It is also measured in urine at a dose of 3.6 g/day. Absorption is poor following ingestion in mice and rats. 38% to 75% of an ingested dose of curcumin is excreted in the feces. Absorption appears to be better with food. Curcumin crosses the blood brain barrier and is detected in CSF.
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