One study presented at the joint meeting of the European and Americas Committees for Treatment and Research in Multiple Sclerosis, found that eight of 15 children with pediatric MS had venous abnormalities when examined with magnetic resonance venography.
Another, conducted in 45 healthy controls and 133 adult MS patients, found signs of CCSVI in about half the patients -- but also in one-third of the controls.
The other studies all either failed to find CCSVI at all in their participant groups, or it was equally distributed between patients and controls.
The latter included one of the largest studies reported so far, with 160 MS patients and 160 healthy controls. Transcranial echo-color Doppler sonography indicated possible CCSVI in 16 patients, but venography found stenoses in only two patients.
For example, a study by Robert Fox, MD, and other researchers at the Cleveland Clinic found that CCSVI-like sonography findings were exquisitely dependent on how the evaluation is carried out.
Interim findings on 42 individuals (including unstated numbers of MS patients and controls) found that 26% had venous reflux when examined with Quality Doppler Profiles technology, but traditional transcranial Doppler scans did not show reflux.
Also, scanning people when seated rather than lying down made a big difference in findings. The study also found that 60% of participants had some type of structural venous abnormality, such as a flap or septum.
It would be interesting to hear how Dr. Fox's opinions on CCSVI might evolve. His own research has been finding intraluminal abnormalities, both in this mentioned study and his autopsy study.