There is no need to rethink.
This forum started as a discussion of published, peer-reviewed research.
The first paper of Dr. Zamboni described four groups of CCSVI.http://jnnp.bmj.com/content/80/4/392.full
One, with azygos blockage, was related to those with progressive MS, called Type D.
These were the most progressed patients, who had spinal lesions and high EDSS scores.
PTA ONLY HELPED IN QUALITY OF LIFE SCORES. It did not change their EDSS.http://csvi-ms.net/en/content/new-zambo ... ment-ccsvi
Hope--Dr. Zamboni always stated that the relief from PTA was in fatigue, cognitive fog and bladder control, which are all neurogenic issues, or the brain-related.
That people should not expect return of motor function due to spinal issues.
What PTA did was give them energy and the verve to pursue physical rehabilitation, a better outlook and desire to live.
He actually said THE SAME THING in his interview I linked just yesterday.
Once taking care of CCSVI, what happens in people with multiple sclerosis?
"MS has ten degrees of severity, ranging from normal to an apparent vegetative state. I can not say to those who are for years in a wheelchair, but surely removing CCSVI the symptom which disappears most, which is chronic fatigue, a fatigue so exhausting before that one cannot take on rehabilitation activities. Moreover, angioplasty strengthens the control of the sphincter. For a disabled person not to pee on himself may be more important than standing. He can return to the interest in life and social relations. "
I said, over and over, my husband was a 1.5 on the EDSS scale, he only had brain lesions that his primary disabilities were in brain fog and fatigue.
He was type C....dual jugular stenosis with no azygos. He responded to PTA the way Dr. Zamboni said he would in his publications.
But this forum took off. Dr. Siskin, Dr. Dake, Dr. Simka and many of the other docs say exactly what Dr. Zamboni has stated in his publications in their own publications. The best responders are those with brain lesions, early in the disease process, and not as much spinal involvement. PTA seems to really help about 33% of pwMS. But again, people report anecdotal things online, and do not read research.
Please, read the published research. PTA will help cerebral blood flow and oxygenation. But the spine is more susceptable to injury, and less able to reroute. The brain is more "plastic" and can recover from injury, due to the recruitment of new neuronal material.
Here's a link to the papers:http://www.ccsvi.org/index.php/advanced ... smaterials
It's not the doctors' fault if the research is not believed-
...and Dr. Tucker, the phlebologists have said from that the "underlying why" in CCSVI is due to intraluminal truncular venous malformations, like the ones noted in autopsies conducted by the Cleveland Clinic. The phlebology publications assert this time and again. So has Dr. Zamboni and Dr. Zivadinov, who note these malformations on doppler US. These webs, septums and malformed valves are know to change blood hemodynamics in other diseases, like Budd Chiari. There may be more ahead, but this is what we have for now.http://www.avidsymposium.com/pdf/vei/4772.pdf
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS