Intra- & Extraluminal Venous Anomalies in MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Intra- & Extraluminal Venous Anomalies in MS

Postby Cece » Mon Dec 26, 2011 1:42 pm

www.ajnr.org/content/early/2011/12/22/a ... 7.abstract

Abstract


BACKGROUND AND PURPOSE: Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular condition characterized by anomalies of the main extracranial cerebrospinal venous routes that interfere with normal venous outflow. Research into CCSVI will determine its sensitivity and specificity for a diagnosis of MS, its prevalence in MS patients, and its clinical, MRI, and genetic correlates. Our aim was to investigate the prevalence and number of intra- and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs.


MATERIALS AND METHODS: One hundred fifty patients with MS, 104 (69.3%) with RR and 46 (30.7%) with a progressive MS course, and 63 age- and sex-matched HCs were scanned with 3T MR imaging by using TOF and TRICKS sequences (only patients with MS). All subjects underwent DS examination for intra- and extraluminal structural and functional abnormalities of the IJVs. Absent/pinpoint IJV flow morphology on MRV was considered an abnormal finding. Prominence of collateral extracranial veins was assessed with MRV.


RESULTS: Patients with MS had a significantly higher number of functional (P < .0001), total (P = .001), and intraluminal (P = .005) structural IJV DS abnormalities than HCs. There was a trend for more patients with MS with extraluminal IJV DS abnormalities (P = .023). No significant differences were found on the MRV IJV flow morphology scale between patients with MS and HCs. Patients with progressive MS showed more extraluminal IJV DS abnormalities (P = .01) and more MRV flow abnormalities on TOF (P = .006) and TRICKS (P = .01) than patients with nonprogressive MS. There was a trend for a higher number of collateral veins in patients with MS than in HCs (P = .016).


CONCLUSIONS: DS is more sensitive than MRV in detecting intraluminal structural and functional venous abnormalities in patients with MS compared with HCs, whereas MRV is more sensitive in showing collaterals.
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Re: Intra- & Extraluminal Venous Anomalies in MS

Postby 1eye » Mon Dec 26, 2011 5:00 pm

what's DS?
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
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Re: Intra- & Extraluminal Venous Anomalies in MS

Postby CureOrBust » Mon Dec 26, 2011 6:55 pm

From the link.
Abbreviations
CCSVI - chronic cerebrospinal venous insufficiency
CV - catheter venography
DS - Doppler sonography
EDSS - Expanded Disability Status Scale
Gd - gadolinium
HC - healthy control
ICC - interclass correlation coefficient
IJV - internal jugular vein
MRV - MR venography
PP - primary-progressive
RR - relapsing-remitting
SP - secondary-progressive
TOF - time-of-flight
TRICKS - time-resolved imaging of contrast kinetics
VV - vertebral veins
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Re: Intra- & Extraluminal Venous Anomalies in MS

Postby Cece » Mon Dec 26, 2011 10:55 pm

Patients with MS had a significantly higher number of functional (P < .0001), total (P = .001), and intraluminal (P = .005) structural IJV DS abnormalities than HCs. There was a trend for more patients with MS with extraluminal IJV DS abnormalities (P = .023). No significant differences were found on the MRV IJV flow morphology scale between patients with MS and HCs. Patients with progressive MS showed more extraluminal IJV DS abnormalities (P = .01) and more MRV flow abnormalities on TOF (P = .006) and TRICKS (P = .01) than patients with nonprogressive MS. There was a trend for a higher number of collateral veins in patients with MS than in HCs (P = .016).

Anyone know what is meant by a functional abnormality? I've got intraluminal abnormalities down. But what would any examples of extraluminal IJV DS abnormalities be? Vein wall narrowing?

It is interesting that they found a difference in patients with progressive MS as compared those with nonprogressive MS.
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