Arch Neurol. 2010 Oct;67(10):1269-71.
Superficial siderosis of the central nervous system due to bilateral jugular vein thrombosis.
Yavagal DR, Geng D, Akar S, Buonanno F, Kesari S.
Department of Neurosciences, Rebecca and John Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093-0819, USA.
To describe a novel cause of meningeal siderosis due to intermittent subarachnoid bleeding caused by chronic bilateral jugular vein thrombosis.
Case report and review of literature.
A 51-year-old man with a distant history of cervical injury who presented with transient aphasia in the setting of progressive cognitive decline.
Neurological examination, magnetic resonance imaging, lumbar puncture, and angiogram.
The patient had intermittent subarachnoid bleeding resulting from extensive venous collaterals in the neck and cervical spine due to chronic bilateral jugular vein thrombosis.
Unexplained neurological deterioration and history of cervical trauma warrants diagnostic consideration of superficial siderosis and jugular vein thrombosis.
While I agree that, based on what is known about CCSVI being a condition of malformed valves or other intraluminal abnormalities or hypoplasias, this is a congenital condition, I also think that in those of us who have the congenital condition of CCSVI, if we were to get a whack on the neck and develop a jugular thrombosis, that would worsen our CCSVI.
This one describes a similar condition to what we have, with extensive venous collaterals in the neck and cervical spine and "chronic" rather than acute jugular blockages, albeit due to thrombosis instead of our typical malformed valves. But this patient suffered from intermittent subarachnoid bleeding as well, presumably as a result of the jugular blockages. Why would this happen in this patient and not in us?
"Superficial siderosis" may be an analagous condition to CCSVI. It occurs when hemosiderin is deposited in the brain due to recurrent bleeding into the cerebrospinal fluid. If indeed this is happening in CCSVI, there is precedence in superficial siderosis that hemosiderin deposited in the brain leads to neurological sequellae.