We're discussing this with Dr. Thibault on Facebook. He says that the venous malformations he's seeeing in CCSVI don't look like truncular venous malformations.
Here's his quote:
Regarding the nature of the venous lesions, I have observed venous diseases closely with ultrasound for the past 24 years and have frequently noted that infalmmation (phlebitis) of the veins will results in localised thrombosis along the wall of the vein, this thrombosis resolves by fibrosis and recanalisation of the vein leaving intraluminal membranes, septa, webs, and fixed and distorted valves. You do not require congenital venous malformations to produce these lesions. I have been looking at these abnormalities in MS patients for the past 2 years, and I personally don't believe that they resemble congenital truncular malformations in any way. This is a very nasty venous vasculitis that we are dealing with, hence the serious consequences.
I'm not completely convinced that it's all about Cpn. I still believe it's more global, and related to endothelial dysfunction. I know a few people who were on the Stratton/Wheldon antibiotic protocol who continued to progress, and one person who was on it and still had stenotic veins. Cpn may be part of the puzzle for some however. I know that Anecdote (Dr. Wheldon's wife who writes in the antibiotic forum here) has recovered from her MS with the antibiotic protocol for Cpn, and she is doing quite well. Obviously, Cpn was involved in her disease process.
I wish it was easier to know what these malformations are...I was pretty sure the autopsy study from Dr. Fox described the valves as something never seen before....really not sure how inflammation could make more leaflets or invert them, but I'm not a phlebologist
But the big picture is that another phelbologist is finding severe venous vasculitis in MS--as Dr. Dake said to Jeff, "I've never seen veins like yours before." This is a serious problem, and we need to get these guys together to figure it out. Inflamed and narrowed veins draining the brain is a dangerous situation....