Recently discovered hormone Irisin

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Recently discovered hormone Irisin

Postby pairOdime » Thu Jan 19, 2012 4:21 pm

Here is some very interesting information on a newly discovered hormone named Irisin. Some are suggesting possible implications for neurodegenerative conditions as well....very interesting.

http://www.ncbi.nlm.nih.gov/pubmed?term=irisin

http://www.nature.com/nature/journal/va ... 10777.html

http://scienceblog.com/51556/scientists ... rn-energy/

The scientists said their findings merely scratch the surface of irisin’s multiple effects. They are continuing to explore the hormone’s possible benefits in metabolic diseases like diabetes, insulin resistance, and obesity, which constitute a growing epidemic around the world, as well as neurodegenerative illnesses like Parkinson’s disease.
Spiegelman added that as growing evidence implicates obesity and physical inactivity in cancer development, it’s conceivable irisin-based drugs may have value in prevention and treatment of the disease.

Nature. 2012 Jan 11. doi: 10.1038/nature10777. [Epub ahead of print]

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.

Dana-Farber Cancer Institute and Harvard Medical School, 3 Blackfan Circle, CLS Building, Floor 11, Boston, Massachusetts 02115, USA.

Abstract
Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-γ co-activator-1 α (PGC1-α). Here we show in mouse that PGC1-α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.

PMID:
22237023
[PubMed - as supplied by publisher]

Of course, there is no substitute for a proper diet and exercise when possible.
It's a paradigm shift
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Re: Recently discovered hormone Irisin

Postby Billmeik » Tue Jan 24, 2012 8:44 am

just a heads up iris in has been talked about here for years now, and it is mentioned in Zamboni's work.
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Re: Recently discovered hormone Irisin

Postby euphoniaa » Tue Jan 24, 2012 9:41 am

Billmeik wrote:just a heads up iris in has been talked about here for years now, and it is mentioned in Zamboni's work.

When I did a "search" for the term, the only other posting here was by Lynda Carol, not too long ago.

post184770.html?hilit=irisin#p184770

I have no idea if it was mentioned by Zamboni.
Dx'd with MS & HNPP (hereditary peripheral neuropathy) 7/03 but must have had MS for 30 yrs before that. I've never taken meds for MS or MS symptoms except 1 yr experiment on LDN. (I found diet, exercise, sleep, humor, music help me the most.)
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Re: Recently discovered hormone Irisin

Postby Billmeik » Sat Jan 28, 2012 7:26 pm

I must be wrong.The chemical Im talking about is't a hormone and has something to do with iron.
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Re: Recently discovered hormone Irisin

Postby Cece » Sat Jan 28, 2012 10:05 pm

It fits with the idea of metabolic dysfunction in MS, doesn't it?
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