Dr. Zamboni's first hypothesis was a compression from bones. Found reflux in veins for 1st time in 2002
From 2002 Dr. Zamboni focused on flow abnormalities & intraluminal anomalies based on looking at pts who died from MS
Dr. Zamboni: CCSVI treatment is about stability, i.e., stopping progression, but it does not work for everyone #CCSVI #ISNVD #MS
Dr. Zamboni: 18 pts treated in actute relapse eith amazing results; must be distinguished from chronic progression #CCSVI #ISNVD
Dr. Zamboni: In acute relapse, improvement comes from improved perfusion; reversal can be quite significant #CCSVI #ISNVD
Dr. Zamboni: first azygos treated Dec 11, 2006; first jugular angioplasty Dec 13, 2006. Then proceeded to begin IRB study.
I did not know that he first found reflux in MS veins back in 2002. That was ten years ago.
No IRs since Dr. Zamboni have set up a study of the CCSVI procedure as a treatment for acute relapse. What if that's the easiest way to show that CCSVI treatment has a benefit? One group of MS patients treated with CCSVI venoplasty during acute relapse; the other group treated with steroids and current standard-of-care. Looking for quicker end to the relapse and less lingering damage at 1 month, 3 months, 6 months. This would not be a hard study to conduct.
Dr. Zamboni: A multidisciplinary team is essential for any centre researching CCSVI. Dr. Z gives credit to his team
Dr. Fox's postmortem studies of MS patients also show intraluminal abnormalities.Dr. Zamboni: post mitten studies showed intraluminal defects in addition to compression from bone