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Short-Term Outcomes After Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency (CCSVI) in Patients with Multiple Sclerosis
A retrospective study of 213 patients treated for CCSVI.
A mean of 2.2 veins treated per procedure.
Now we're starting to look at who are responders and who are not. I don't think patient selection should be limited to RRMS and PPMS just because improvement occurred less often in SPMS. Physical health improvement was seen in 59% of patients with SPMS. Mental health improvement was seen in 50% of patients with SPMS. Those are still high percentages, even if the RRMSers were higher.CONCLUSIONS:
Endovascular treatment of CCSVI can produce
significant, short-term improvement in physical and mental healthrelated
QOL. However, improvement occurred less often in patients
with SPMS than in patients with RRMS and PPMS. In addition, while
the years since MS diagnosis did not appear to be related to QOL
improvement after angioplasty, the frequency of improvement was
less in patients with >10 yrs since MS diagnosis when compared
with patients diagnosed within 10 years of the procedure. While this
retrospective data is encouraging, a prospective randomized trial
is needed to rigorously evaluate the role of endovascular CCSVI
treatment in MS and to understand the implications of the present
study in terms of patient selection.