Dr. Benedict at ISNVD

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Dr. Benedict at ISNVD

Postby Cece » Tue Feb 21, 2012 2:27 pm

from page 45 of the isnvd 2012 abstracts http://www.isnvd.org/files/ISNVD%20Abstract%20Book.pdf
Cognitive outcomes in MS (Ralph Benedict, USA)

Multiple sclerosis (MS) is associated with cognitive deficits that include problems in auditory/verbal memory,
visual/spatial memory, cognitive processing speed/working memory, and executive control/function. Given that
an extensive battery to assess these varied domains is not feasible in most clinical trials, brief cognitive
assessments have been proposed that are psychometrically sound regarding sensitivity, reliability, and validity.
In this presentation, the speaker will summarize the results from two task forces on this topic: [a] the NINDS
Common Data Elements Work Group, and [b] the Brief International Cognitive Assessment for MS (BICAMS).
Both programs have recommended the Symbol Digit Modalities Test, a measure of cognitive processing speed,
for MS clinical trials. In addition, memory and executive function outcomes have been suggested for
circumstances that permit a more comprehensive assessment. Future work is planned to further validate these
outcomes with respect to clinically meaningful change.
This is a simple cognitive test that can be done pre- and post- CCSVI treatment. This may be an important part of research design for CCSVI, since diminished cognitive abilities is part of the CCSVI symptom complex that may be relieved by CCSVI treatment. The Symbol Digits Modalities Test!
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