Autoimmune response after stroke

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Autoimmune response after stroke

Postby Cece » Wed Mar 14, 2012 6:53 am ... 1/S75.full

Cheer posted this over at the Facebook site. Any thoughts?

Modulation of the Postischemic Immune Response to Improve Stroke Outcome

Kyra J. Becker, MD
From the University of Washington School of Medicine, Seattle, Wash.

Recent advances in understanding how the poststroke immune response may contribute to ischemic brain injury are discussed in this article. In particular, the potential of modulating the postischemic immune response to improve stroke outcome is explored.
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Re: Autoimmune response after stroke

Postby pollyanna » Sat Mar 17, 2012 9:35 pm

CeCe, thanks, have been revisiting this theory....
Makes very good sense......
Gosh, excellent sense.....
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Re: Autoimmune response after stroke

Postby cheerleader » Sun Mar 18, 2012 9:15 am

Thanks for posting, Cece--
These five points seem exceedingly important for pwMS to understand.

1. There is an autoimmune response after ischemic injury to the brain.
2. Lymphocytes from stroke survivors show more activity against myelin basic protein than the lymphocytes from patients with multiple sclerosis
3. Myelin-reactive T cells are found in higher numbers among patients with cerebrovascular disease
4. Stroke is a potent risk factor for dementia, and it could be that autoimmune responses to brain injury contribute to cognitive decline and even the progression of white matter disease.
5. This researcher considers immune modulating drugs to be too dangerous to use after stroke, due to risk of infection in the brain (think JC virus and PML)

This is why it's so important to discover the real pathogenesis of MS.
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
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