Degeneration vs autoimmunity in MS

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Degeneration vs autoimmunity in MS

Postby Cece » Wed May 16, 2012 8:19 am

“Importantly, despite even potent modulation of the immune system, which results in profound reduction of inflammatory lesions, the effect on long-term disability and progression is not as robust as we would expect or hope for, and treatment of progressive disease has thus far been a failure”

Tsutsui S, Stys P. 2009. “Degeneration versus autoimmunity in MS.”

https://www.facebook.com/notes/ccsvi-in ... 4943239919
From CCSVI in MS Toronto.
Cece
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Re: Degeneration vs autoimmunity in MS

Postby tedhutchinson » Thu May 17, 2012 9:48 am

Cece wrote:
“Importantly, despite even potent modulation of the immune system, which results in profound reduction of inflammatory lesions, the effect on long-term disability and progression is not as robust as we would expect or hope for, and treatment of progressive disease has thus far been a failure”

Tsutsui S, Stys P. 2009. “Degeneration versus autoimmunity in MS.”

https://www.facebook.com/notes/ccsvi-in ... 4943239919
From CCSVI in MS Toronto.

It's only a short editorial piece, I've the full text PDF if anyone wants a read PM me your email addy and I'd copy it to you.
He goes on to point out that
despite a potent suppression of inflammation with the humanized antileukocyte antibody Campath-1H, a substantial proportion of patients continued to experience progressive disability and brain atrophy
Well it's true with a lot of medications that however aggressively the "numbers" are targeted (blood pressure ~ diabetes are typical examples) and brought down to supposedly "safe" levels that isn't reflected in all cause mortality reductions. While it may be true that treating numbers artificially reduces those numbers but not the risks associated with high numbers, it may also be the case that improving control of inflammation NATURALLY by ensuring vitamin d, magnesium omega 3, melatonin levels are at what might reasonably be regarded as evolutionary norms a NATURAL suppression of inflammation may produces more advantageous results.
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