commonalities between MS and Alzheimer's

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

commonalities between MS and Alzheimer's

Postby Cece » Wed May 16, 2012 8:58 am
J Neural Transm. 2011 May;118(5):747-52. Epub 2011 Mar 5.

Mechanisms of neurodegeneration shared between multiple sclerosis and Alzheimer's disease.

Lassmann H.

Center for Brain Research, Medical University of Vienna, Wien, Austria.


Multiple sclerosis and Alzheimer's disease are fundamentally different diseases. However, recent data suggest that certain mechanisms of neurodegeneration may be shared between the two diseases. Inflammation drives the disease in multiple sclerosis. It is also present in Alzheimer's disease lesions, where it may have dual functions in amyloid clearance as well as in the propagation of neurodegeneration. In both diseases, degeneration of neurons, axons, and synapses occur on the background of profound mitochondrial injury. Reactive oxygen and nitric oxide intermediates are major candidates for the induction of mitochondrial injury. Radicals are produced through the induction of the respiratory burst in activated microglia, which are present in the lesions of both diseases. In addition, liberation of toxic iron from intracellular stores may augment radical formation. Finally reactive oxygen species are also produced in the course of mitochondrial injury itself. Anti-oxidant and mitochondria protective therapeutic strategies may be beneficial both in multiple sclerosis and Alzheimer's disease in particular in early stages of the disease.

Treatment of CCSVI may have a beneficial impact on the mitochondria. A candidate for mitochondrial injury, in addition to what is listed above, is a reduction in availability of nutrients due to the slowed perfusion or hypertension of CCSVI.

Antioxidant and mitochondria protective therapeutic strategies may be beneficial. As other research suggested, we should all be eating berries.
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Re: commonalities between MS and Alzheimer's

Postby AnCap » Wed May 16, 2012 1:59 pm

Inflammation drives MS? This paper is worthless.
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Re: commonalities between MS and Alzheimer's

Postby tedhutchinson » Thu May 17, 2012 5:06 am

AnCap wrote:Inflammation drives MS? This paper is worthless.

Inflammation-Mediated Memory Dysfunction and Effects of a Ketogenic Diet in a Murine Model of Multiple Sclerosis
Full text at link.
A prominent clinical symptom in multiple sclerosis (MS), a progressive disorder of the central nervous system (CNS) due to heightened neuro-inflammation, is learning and memory dysfunction.
Here, we investigated the effects of a ketogenic diet (KD) on memory impairment and CNS-inflammation in a murine model of experimental autoimmune encephalomyelitis (EAE), using electrophysiological, behavioral, biochemical and in vivo imaging approaches.
Behavioral spatial learning deficits were associated with motor disability in EAE mice, and were observed concurrently with brain inflammation.
The KD improved motor disability in the EAE model, as well as CA1 hippocampal synaptic plasticity (long-term potentiation) and spatial learning and memory (assessed with the Morris Water Maze).
Moreover, hippocampal atrophy and periventricular lesions in EAE mice were reversed in KD-treated EAE mice.
Finally, we found that the increased expression of inflammatory cytokines and chemokines, as well as the production of reactive oxygen species (ROS), in our EAE model were both suppressed by the KD.
Collectively, our findings indicate that brain inflammation in EAE mice is associated with impaired spatial learning and memory function, and that KD treatment can exert protective effects, likely via attenuation of the robust immune response and increased oxidative stress seen in these animals.

A ketogenic diet improves mitochondrial function hence we see people like Dr Wahls making progress on a diet that avoids refined carbohydrates and sugars. There are plenty of people with AD who are using Coconut oil because it's a high source of Medium Chain Triglycerides that are easily/quickly converted to ketones and available as fuel for damaged brains. One of the reason human milk is rich in MCT is that its the best fuel for the growing brain.
Bring back butter.
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Re: commonalities between MS and Alzheimer's

Postby Cece » Thu May 17, 2012 5:15 am

I use coconut oil too, for that reason.
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