IRON - is it the real culprit

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

IRON - is it the real culprit

Postby Beaufighter » Wed May 23, 2012 6:40 am

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Re: IRON - is it the real culprit

Postby jimmylegs » Wed May 23, 2012 1:07 pm

it is not the fundamental culprit, we've been over this repeatedly here, but i'll beat the dead horse once more: as the article suggests, there are some strong associations between zinc deficiency resulting from the alcohol and possible gluten, or any other dietary zinc drain, such as gluten grains, sugar, etc, that can lead to iron overload. what they didn't mention is that zinc repairs liver cirrhosis (in rats at least)

Zinc counteracts experimentally-induced cirrhotic changes in rats
http://www.ncbi.nlm.nih.gov/pubmed/8225551

here's one related human study at least:

Effects of zinc deficiency/zinc supplementation on ammonia metabolism in patients with decompensated liver cirrhosis
http://www.lib.okayama-u.ac.jp/www/acta ... _6_349.pdf

if interested try the forum search to find links to studies on zinc deficiency and iron dysregulation.
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Re: IRON - is it the real culprit

Postby Beaufighter » Sat May 26, 2012 11:02 am

I read this earlier and checked out the links....

I feel that MS is a result of three things, Possibly stating the obvious.

Stenosis
Time
Iron content of diet especially water soluble iron.

Draw yourself a simple Venn diagram, Assign each circle one of the above.

The intersection is MAY be when MS occours.

Have a look at this please

http://en.wikipedia.org/wiki/File:Multi ... HO2002.svg

and this.

http://www.who.int/vmnis/anaemia/preval ... naemia.pdf

It is the iron in our diets combined with CCSVI that causes MS.

Of note is this country, it sticks out like a sore thumb.... and is a paradox

http://geography.about.com/library/cia/ ... guiana.htm

Why do they have such a prevalence of MS when the others surrounding countries do not ???

The Geology of this nation tells the story, High in water soluble iron it looks like, and it gets into all the foods, plants etc, ( still researching). Friends of mine are from the area have have extremely high levels of iron in their blood that has alarmed their Canadian Doctors.

If you draw a venn diagram and assign Stenosis to one circle, Time to the other and Diet / iron to the third the intersection of these produces MS

The larger any one of the circles is the greater the chance of having MS. If you do not have CCSVI then you will not get Clinically defined MS. If you have a diet with no iron, you will not get MS. (this is impossible though as Iron is in everything). Time is time and you cannot eliminate that.

I have reduced iron in my diet. I have reduced Vitamin C in all forms completely becuase

http://www.ncbi.nlm.nih.gov/pubmed/3304065

Ann N Y Acad Sci. 1987;498:324-32.

Is there a physiological role of vitamin C in iron absorption?
Hallberg L, Brune M, Rossander-Hulthén L.

Nonheme iron usually constitutes more than 90% of the dietary iron. Its absorbability is a resultant of the balance between factors enhancing and inhibiting the absorption. Ascorbic acid is the most potent enhancer, and is the same for native and synthetic AA. The enhancing effect is strongly dose related (log dose/effect), and is different for different meals probably mainly due to varying content of inhibitors in the meals. AA also increases the iron absorption from simple meals with no known inhibitor, probably because AA impairs the formation of unavailable iron complexes with ligands normally present in the gastrointestinal lumen. The effect of AA is so unequivocal and marked that it must be considered as a physiological factor essential for the absorption of dietary iron.

PMID: 3304065 [PubMed - indexed for MEDLINE]

I will somehow get the CCSVI operation.

I have to get back to work now.

Gord

PS sorry about the spelling (Cheerleader !)
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