advanced sonological protocol from Italian study

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

advanced sonological protocol from Italian study

Postby Cece » Fri Jun 01, 2012 6:15 pm

http://www.sciencedirect.com/science/ar ... 8X12000848

Italian multicenter study on venous hemodynamics in multiple sclerosis: Advanced Sonological Protocol

Introduction: Because of the recent hypothesis of involvement of the venous hemodynamics in multiple sclerosis (MS), and because of the pitfalls of these studies, there is the need to achieve a definite conclusion from a large sample of subjects by using a strict and controlled neurosonological protocol. The aim of the advanced protocol, designed for a subgroup of the FISM study, is to analyze several items of the venous hemodynamics in order to obtain more pathophysiological data on venous circulation. Advanced Ultrasound Protocol: This is a multicenter, observational study. From a pool of about 1200 adults with MS, 400 healthy subjects and 400 subjects with other neurodegenerative disorders (2000 subjects in total) will be selected a population able to be examined by the advanced protocol. The examiner will always be blind on the clinical diagnosis, and the exams will be performed according to a standard protocol, whose measurements are mandatory for all participating centers. The advanced protocol is on a voluntary basis and it is optional. It includes, besides the basic one, measurements of blood flow volumes in carotid and vertebral arteries and in jugular and vertebral veins (inflow and outflow), with the definition of the drainage pattern. The ultrasound examination at each clinical site will be followed by a second centralized blinded evaluation. The prevalence of CCSVI in MS will be estimated, with confidence intervals at 95%, and compared with the prevalence in other groups. Moreover, multiple analysis will be done comparing venous hemodynamics in the three different groups.

The article is available in full, with images, but I haven't had a chance to read it.
Cece
Family Elder
 
Posts: 9054
Joined: Mon Jan 04, 2010 3:00 pm

Advertisement

Re: advanced sonological protocol from Italian study

Postby 1eye » Sat Jun 02, 2012 1:28 am

This is multi-centre. As such, its numbers will probably assume statistical significance, for those who care about such things. The study is also being run by mostly Italian neurologists. Any judgement I may still possess is reserved for later, but it could be the makings of a Good Thing.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
User avatar
1eye
Family Elder
 
Posts: 2999
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada

BEWARE of advanced sonological protocol from Italian study

Postby MarkW » Sat Jun 02, 2012 2:35 am

After a quick scan of this paper my comment is BEWARE. My guess is that the Neuros who collected this data are trying to show that Prof Zamboni's criteria are not good science. Let's go back to the simple mantra that gold standard diagnosis of CCSVI syndrome requires an invasive procedure using catheter venography and intravascular ultrasound.
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
User avatar
MarkW
Family Elder
 
Posts: 1151
Joined: Thu Oct 19, 2006 2:00 pm
Location: Oxfordshire, England

Re: advanced sonological protocol from Italian study

Postby 1eye » Sat Jun 02, 2012 7:31 am

MarkW wrote:...Let's go back to the simple mantra that gold standard diagnosis of CCSVI syndrome requires an invasive procedure using catheter venography and intravascular ultrasound.
MarkW
Yep, and why would you run a multi-centre study on a screening tool? If they wanted to test IVUS, I would sit up and take notice. But then they'd have to a) pay money and b) talk fast.
"Try - Just A Little Bit Harder" - Janis Joplin
CCSVI procedure Albany Aug 2010
'MS' is over - if you want it
Patients sans/without patience
User avatar
1eye
Family Elder
 
Posts: 2999
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada

Re: advanced sonological protocol from Italian study

Postby Cece » Sat Jun 02, 2012 8:14 am

They're also looking at inflow, despite CCSVI being a matter of outflow obstructions. They're looking at blood flow volume in the outflow veins and at the "drainage pattern." It's not mentioned in the introduction if they are looking at blood flow stasis, retrograde flow, or visible valvular obstructions. I still have to read the article.

It should be noted that, for the vertebral artery and carotid artery measurements being taken, the gold standard is MR phase-contrast quantification, and not sonological data at all. http://www.ajnr.org/content/27/2/363.full
Cece
Family Elder
 
Posts: 9054
Joined: Mon Jan 04, 2010 3:00 pm

Re: advanced sonological protocol from Italian study

Postby masci » Sun Jun 03, 2012 9:48 am

Baracchini & Al are known v CCSVI. Their studies have often been criticized by prof. Zamboni.
In previous studies, has been matched CCSVI / MS = 0
User avatar
masci
Getting to Know You...
 
Posts: 23
Joined: Fri Sep 25, 2009 2:00 pm


Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service