3rd Annual ISNVD Scientific Meeting (Poland 2013)

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Sun Jun 10, 2012 4:27 pm

I know, I know, summer just began, and the next ISNVD isn't until midwinter next year. But it sounds fantastic.
Tentative Schedule of Events

Saturday - February 23, 2013
8:00am – 9:00am Registration of Workshop participants
9:00am – 11:00am Workshop on trans cranial Doppler
9:00am – 11:00am Workshop on Doppler examination of neck veins
9:00am – 11:00am Workshop on trans esophageal Doppler examination of azygous vein
9:00am – 11:00am Workshop on evaluation of MRV in CCSVI Patients
11:00am – 11:30am Coffee Break
11:30am – 1:00pm How do I do it: IVUS in CCSVI Patients
11:30am – 1:00pm How do I do it: PTA and cutting balloons in CCSVI Patients
11:30am – 1:00pm Workshop: How to set up an acute stroke service
11:30am – 1:00pm Workshop on MR and CT assessment in stroke patients
1:00pm – 2:30pm Lunch
2:30pm – 4:30pm Workshop on trans cranial Doppler
2:30pm – 4:30pm Workshop on Doppler examination of neck veins
2:30pm – 4:30pm Workshop on trans esophageal Doppler examination of azygous vein
2:30pm – 4:30pm Workshop on evaluation of MRV in CCSVI Patients
4:30pm – 5:00pm Coffee Break
5:00pm – 6:30pm How do I do it: IVUS in CCSVI Patients
5:00pm – 6:30pm How do I do it: PTA and cutting balloons in CCSVI Patients
5:00pm – 6:30pm Workshop: How to set up an acute stroke service
5:00pm – 6:30pm Workshop on MR and CT assessment in stroke patients
8:00pm – 11:00pm Meet-together for workshop participants

Sunday - February 24, 2013
8:00am – 9:00am Registration for ISNVD Annual Meeting
9:00am – 9:30am Official opening of the ISNVD Annual Meeting
9:30am – 11:00am Acute stroke management: session1 – basic science and prevention
9:30am – 9:50am Stroke in animal models
9:50am – 10:10am Asymptomatic carotid stenosis: who should be treated?
10:10am – 10:30am TBD
10:30am – 10:50am TBD
10:50am – 11:00am Panel Discussion
11:00am – 11:30am Coffee Break with Poster session 1
11:30am – 1:00pm Acute stroke management: session 2 – Diagnosis and treatment
11:30am – 11:50am How to set up an acute stroke service
11:50am – 12:05pm Emergence CT and MR imaging in stroke patients
12:05pm – 12:25pm Mechanical trombectomy in acute stroke
12:25pm – 12:40pm Systemic vs. local fibrinolysis in acute stroke
12:40pm – 12:45pm Percutaneous left atrial appendage closure for stroke prophylaxis
12:45pm – 1:00pm Panel discussion and closing remarks
1:00pm – 2:30pm Lunch
2:30pm – 4:30pm CCSVI session 1 – Ultrasonography
2:30pm – 2:45pm Cerebral circulation time in MS patients
2:45pm – 3:00pm Quantitative color Doppler evaluation of cerebral venous outflow in MS patients
and healthy controls
3:00pm – 3:15pm How reliable are current sonographic CCSVI criteria
3:15pm – 3:30pm Comparison between ultrasound and venography in MS patients
3:30pm – 3:45pm Transesophageal sonographic assessment of the azygous vein
3:45pm – 4:00pm Prevalence of CCSVI in MS patients and healthy controls
4:00pm – 4:30pm TBD
4:30pm – 5:00pm Coffee Break with Poster session 2

Sunday - February 24, 2013 (con’t from page 16)
5:00pm – 6:30pm CCSVI session 2 – Clinical trials on CCSIV
5:00pm – 5:15pm Meta-analysis of open-label interventional studies on CCSVI
5:15pm – 5:25pm Current status of RCT on CCSVI: Italy
5:25pm – 5:35pm Current status of RCT on CCSVI: USA
5:35pm – 5:45pm Current status of RCT on CCSVI: USA
5:45pm – 5:55pm Current status of RCT on CCSVI: Australia
5:55pm – 6:15pm Panel Discussion
6:30pm – 8:00pm Welcome reception (free of charge)

Monday - February 25, 2013
8:00am – 9:00am Registration for ISNVD Annual Meeting
9:00am – 10:00am Venous disorders in non-MS neurologic pathologies
9:00am – 9:15am Abnormal MRI drainage pattern in Parkinson disease
9:15am – 9:30am Venous drainage in MS and migraine
9:30am – 9:45am Abnormal arterial vasculature in Parkinson disease
9:45am – 10:00am Cerebral venous hemodynamics in chronic disorders of cerebral circulation
10:00am – 10:15am TBD
10:15am – 10:30am TBD
10:30am – 11:00am Coffee Break with Poster session 3
11:00am – 11:30am Key note Lecture: TBD
11:30am – 1:00pm CCSVI session 3 – endovascular and surgical interventions for CCSVI
11:30am – 11:45am Endovascular interventions in other venous territories
11:45am – 12:00pm Venous angioplasty using cutting balloons
12:00pm – 12:15pm The role for IVUS in decision making
12:15pm – 12:30pm Redo angioplasty in CCSVI patients
12:30pm – 12:45pm TBD
12:45pm – 1:00pm Panel Discussion
1:00pm – 2:30pm Lunch
2:30pm – 4:30pm TBD
4:30pm – 5:00pm Coffee Break with Poster session 4
5:00pm – 6:00pm CCSVI session 5 – MRI
5:00pm – 5:15pm Quantitative MRV in MS patients
5:15pm – 5:30pm MR hemodynamic changes in MS and CIS
5:30pm – 5:45pm Positional venous MR angiography
5:45pm – 6:00pm TBD
6:00pm – 6:30pm Closing Session
8:00pm – 11:00pm Gala Dinner

Trans esophageal Doppler examination of azygous vein! We talked about that here a few months ago, I thought it was not particularly viable? But maybe it is! I'll bump that thread.

Current status of RCTs in various countries (Italy, USA, USA again, and Australia)...I expect this will be on all future ISNVD schedules as more and more randomized controlled trials get underway. We are getting somewhere even when it feels as if we aren't.

Endovascular interventions in other venous territories - this would include the Nutcracker syndrome, and stenting of the renal vein to improve CCSVI symptoms.

Interesting that cutting balloons is still on the docket. Is there a case to be made for cutting balloons?

Redo angioplasty in CCSVI patients - this is a matter of growing concern, as a fair number of patients who have had the procedure done have gone on to have it again. I am counted among that number. The challenges are different in a redo than in a first procedure.

Positional venous MR angiography - what's this mean? Positional MRV? Upright MRV, perhaps?

Management of stroke comprises a significant portion of the schedule. All CCSVI, all the time, it is not, alas. But mostly CCSVI, most of the time, that's good enough. :)
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Sun Jun 10, 2012 4:33 pm

Cece wrote:Trans esophageal Doppler examination of azygous vein! We talked about that here a few months ago, I thought it was not particularly viable? But maybe it is! I'll bump that thread.

Or maybe not! Dr. Sclafani offered this assessment of the transesophageal doppler of the azygous, two years ago:
drsclafani wrote:
drbart wrote:How about using TEE for imaging the azygos?

Might require a sedative, but you don't have the issues of blood, thinning, hyper-sterility, or post-op treatment.


Bart
with tee (TRANSESOPHAGEAL ECHO), a large probe is place through the esophagus to look at structures in the chest near the esophagus.

i dont think it will show the vein over its entirely, has higher risk because of sedation and risk of perforation of the esophagus. I dont think i would explore its use.

sterility iis a good thing. infection is uncommon in vascular procedures where catheters are not left in long-term.

venography is relatively benign, does not require blood thinners or more than an hour of post procedural observation
the risk is higher

chronic-cerebrospinal-venous-insufficiency-ccsvi-f40/topic10680-2925.html#p126912
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Wed Aug 15, 2012 7:41 pm

http://www.isnvd.org/files/ISNVD-2013.pdf
ISNVD was founded to promote research in
the field of CCSVI
 Lessons can be learnt from the management of
carotid artery stenosis:
 only a multidisciplinary approach can guarantee
the success
 Should the goals of the Society be met, the
doctors from different areas MUST be attracted

Management of acute stroke
 Stroke is potentially curable
 But requires orchestrated and
multidisciplinary approach
 This is a hot topic that should attract
doctors (neurologists) and companies

So the discussion of stroke is to attract vascular-minded neurologists?
Ok, I can live with that.

I am however curious about the Dragon.
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Sun Oct 14, 2012 1:22 pm

http://www.isnvd.org/index.php?site=3rd ... 13#content
3rd Annual Meeting - Invited Speakers

Invited Speakers

Duong, T.Q. (USA) Stroke in animal models

Fry, S. (USA) Infection with protozoan Protomyxzoa rheumatica and its potential role in neurovascular disease

Grunwald, I.Q. (UK) How to set up an acute stroke service

Haacke, E.M. (USA) Abnormal MRI venous drainage pattern in Parkinson disease

Jannetta, P.J. (USA) Abnormal arterial vasculature in Parkinson disease

Liasis, N. (Greece) The role for carotid artery screening in stroke prevention

Lugli, M. (Italy) Comparison between ultrasound and venography in MS patients

Mancini, M. (Italy) Cerebral circulation time in MS patients

Menegatti, E. (Italy) Transcranial Doppler evaluation of cerebral veins

Monti, L. (Italy) Quantitative sonography of cerebral venous outflow in MS patients

Niggemannn, P. (Germany) Upright MR venography of internal jugular veins

Papadaki, E.Z. (Greece) MR venography abnormalities in MS and clinical isolated syndrome patients

Raju, S. (USA) Endovascular interventions in venous territory

Siddiqui, A. (USA) Clinical trials on cerebral stroke

Sievert, H. (Germany) Mechanical trombectomy in acute stroke

Valk, J. (Netherland) Cerebral venous return and chronic neurological disorders

Wiechowska-Kozlowska, A. (Poland) Transesophageal sonography of the azygous vein

Urbanek, T. (Poland) Meta-analysis of interventional studies on CCSVI

Zivadinov, R. (USA) CCSVI in pediatric MS and other neurologic diseases
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby HappyPoet » Sun Oct 14, 2012 4:22 pm

Hi Cece,
I don't see your name listed in the speaking schedule, so you must be taking one of the TBD (to be determined) slots, yes? ;)

Also, as this quote shows, you correctly answered your own question (in your first post) about "positional MR angiography"
Niggemannn, P. (Germany) Upright MR venography of internal jugular veins

I wonder if this doctor uses the FONAR Upright MRI machine.
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Robnl » Mon Oct 15, 2012 2:02 am

There is a difference between invited speakers and the definitive list

K. Bartuś (Poland)
]◦ T.Q. Duong (USA)
◦ S. Fry (USA)
◦ I.Q. Grunwald (United Kingdom/Germany)
◦ E.M. Haacke (USA)
◦ P.J. Jannetta (USA)
◦ D. Kucera (Czech Republic)
◦ N. Liasis (Greece)
T. Ludyga (Poland)[/FONT]
◦ M. Lugli (Italy)
◦ M. Mancini (Italy)
◦ E. Menegatti (Italy)
◦ L. Monti (Italy)
◦ P. Niggemann (Italy)
◦ E.Z. Papadaki (Greece)
◦ S. Raju (USA)
◦ S. Sclafani (USA)
◦ A. Siddiqui (USA)
[ M. Simka (Poland)
◦ H. Sievert (Germany)
◦ J. Valk (Netherlands)
◦ A. WiechowskaKozłowska (Poland)
◦ T. Urbanek (Poland)
◦ R. Zivadinov (USA)
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Mon Oct 15, 2012 10:23 am

HappyPoet, I wish I was going and could take the backmost seat at every presentation and soak it all in.

Yes, he was using the FONAR upright MRI, at least in this research:
http://www.ajnr.org/content/early/2011/ ... 4.abstract
Positional Venous MR Angiography: An Operator-Independent Tool to Evaluate Cerebral Venous Outflow Hemodynamics
P. Niggemann, M. Seifert, A. Förg, H.H. Schild, H. Urbach and T. Krings

From the Department of Radiology (P.N., M.S., H.H.S., H.U.), University of Bonn, Bonn, Germany; Privatpraxis für Upright MRT (A.F.), Aschheim, Germany; and Department of Neuroradiology (T.K.),Toronto Western Hospital, Toronto, Ontario, Canada.

Abstract

BACKGROUND AND PURPOSE: CCSVI has been proposed as a cause for MS. According to this theory, strictures of the IJV are among the described causes for CCSVI. Little is known about their influence on the hemodynamics of the CVBO. We used positional MR imaging to describe the influence of positional changes on the CVBO.

MATERIAL AND METHODS: Using the Fonar Upright MR imaging system, we performed venous time-of-flight angiography of the cervical region in the supine and sitting positions in 15 healthy volunteers. The image quality was rated; the positional findings and interindividual variances in the CVBO were analyzed.

RESULTS: A venous time-of-flight angiography of the cervical spine was feasible with good image quality. Strictures of 1 or both IJVs were found in 8 of 15 healthy volunteers in the supine position; however, none were visible in upright position. The IJV was not the main outflow route in the erect position. No relevant venous reflux was observed.

CONCLUSIONS: IJV strictures are a common finding in healthy volunteers in the supine position. They seem to be of no relevance in the erect position. This finding questions the validity of this criterion for the diagnosis of CCSVI. Reflux into the venous system was not visualized, and it remains to be seen whether it can be identified in patients with MS. Positional MR imaging enables operator-independent evaluation of the CVBO and may help to clarify the validity of the criteria for CCSVI.

HP, you asked a different day about how the body switches from one main drainage route to the other upon going from supine to upright. I ran across this. ACC is anterior condylar confluent. http://lib.bioinfo.pl/paper:12372739
The ACC offered multiple connections with the dural venous sinuses of the posterior cranial fossa, the internal jugular vein, and the vertebral venous system.
The ACC is a constant anatomic structure that may play an important role in the redirection of cerebral blood in the craniocervical region.
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Tue Feb 12, 2013 9:13 pm

I ran across this in my search for recent google scholar articles on CCSVI.

Dr. Siddiqui presented on PREMiSe a week ago in Hawaii (lucky doc) at a stroke conference.
PREMiSe is the small randomized controlled trial of CCSVI venoplasty. Ten patients treated, ten sham treated.

It is interesting to see an IR presenting on CCSVI at a stroke conference. Along with the stroke presentations happening later this month at ISNVD. The stroke doctors have experience and knowledge of the effects of blocked cerebral blood flow. I wonder what they will add to the conversation.

http://www.snisonline.org/Conference/up ... sed_22.PDF
3rd SNIS International Endovascular Stroke Conference (IESC) and Joint Cerebrovascular Section Annual Meeting
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Tue Feb 12, 2013 9:23 pm

Here's another conference coming up in May
32 5:00 PM - 6:30 PM 1.5 Special Session: Controversies in Neuroradiology
5:00 PM - 5:30 PM Brain Imaging Controversies: DTI in the Clinic: To Be or Not To Be
Pro Timothy P. L. Roberts, PhD
Con Pratik Mukherjee, MD, PhD
Brain Imaging Controversies: CCSVI: Is There Venous Insufficiency in MS or Not?
Pro Greg G. Zaharchuk, MD, PhD
Con Aaron S. Field, MD, PhD

http://members.asnr.org/meeting/annualmeeting.pdf
ASNR 51st Annual Meeting San Diego, California
Who are Dr. Zaharchuk and Dr. Field? I would like the Pro side to be well represented...

This is a neuroradiology conference. Between this and the presentation at the stroke conference cited above, this is the first time CCSVI has been covered by disciplines other than neurology (AAN) and interventional radiology (SIR, ISET), isn't it?
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby cheerleader » Tue Feb 12, 2013 11:01 pm

Cece wrote:Who are Dr. Zaharchuk and Dr. Field? I would like the Pro side to be well represented...


Dr. Zaharchuk has worked and published with Dr. Dake. I'm pretty sure he was in the room during one of Jeff's procedures.
Here's a publication he co-authored:
http://www.ajnr.org/content/32/8/1482.short

good find on the other conferences, Cece. Glad to see other cerebrovascular doctors looking at CCSVI.
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dx dual jugular vein stenosis (CCSVI) 4/09
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Wed Feb 13, 2013 9:34 am

Ah! I am happy with his credentials then! That's the Dr. Dake paper on his patients from 2009.
For the con side, we have Dr. Field from Wisconsin who turns out to be one of the doctors who is conducting one of the 7 MS Society studies.
"I am excited just because it would be such a tremendous boon to therapy for MS patients," said Dr. Field in his interview. "They've been waiting a long time for meaningful therapy."

https://www.radiology.wisc.edu/newsContent.php?id=368
That was from back when his study was commencing. He is a neuroradiologist, thus why he is presenting at a neuroradiologist conference. Seems like a good guy.
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Sun Feb 24, 2013 3:42 pm

*bump*
don't we normally get the ISNVD abstracts???
The program is here: http://tinyurl.com/aw7wau2

Look at this poster presented earlier today:
Feasibility and safety of endovascular treatment for chronic cerebrospinal venous insufficiency in a cohort of 1202 patients with multiple sclerosis. Tommaso Lupattelli (Italy)

1,202 patients!! The numbers are getting big.
Hemodynamics and treatment response in vein stenosis: Lessons from iliac stent experience. Seshadri Raju (USA)

Dr. Raju is a veins expert.
The role for IVUS in decision making. Salvatore Sclafani (USA)

Our hometown hero here at TiMS.
Comparison of IVUS to gold standard catheter venography for detection of extra-cranial venous abnormalities indicative of CCSVI: results of the PREMiSe study. Adnan Siddiqui (USA)

yes please
Lessons learned from already performed interventional studies on CCSVI. Michael D. Dake (USA)
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby cheerleader » Mon Feb 25, 2013 7:21 pm

Cece wrote:*bump*
don't we normally get the ISNVD abstracts???


Frustrating this year. No online abstracts and no reports back from Arlene Hubbard or any attendees. I know Carol Schumacher (Annette Funicello Research Fund) is there---but I'm not seeing any chatter from the weekend online. The twitter feed from ISNVD is from last year, too :?

What happens in Krakow stays in Krakow?
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Ernst » Tue Feb 26, 2013 5:11 am

Im also eagerly waiting news from Poland meeting. Video lectures, hopefully we can see them..like last year from Florida. If you havent seen, check this priceless link:

2nd Annual ISNVD Conference and Webinar - Videos
My wife's 3 yrs post video: http://www.youtube.com/watch?v=eLeqLps8XR8

Our family: http://www.youtube.com/watch?v=p_QCKxeQAlg
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Re: 3rd Annual ISNVD Scientific Meeting (Poland 2013)

Postby Cece » Tue Feb 26, 2013 8:44 am

Arlene posted on Facebook that Dr. Hubbard was sick or not feeling well, and that they weren't able to attend.
Did you see Carol's glass creations for this year's ISNVD? Dragons. Really nice.

There was talk at last year's ISNVD about establishing an ISNVD journal. Could that be why we haven't gotten the abstracts, if they are going into the journal?
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