David1949 wrote:
The bottom line is; human beings are not rodents.... well most of us anyway.
Agreed, David! Copaxone cures mice of EAE (lucky rat bas***ds)
Here's a study in human brains---albeit aging humans.
Quote:
Prior research has demonstrated links among vascular health and the occurrence of stroke, mild cognitive decline, and dementia in older adults. However, little is known about whether normal variation in vascular indicators may be related to changes in neural tissue integrity. Even less is known about how the brain is affected by cholesterol levels in the normal to moderate risk range, leading up to overt disease pathology. This study examined associations between serum lipid levels and DTI indicators of white matter (WM) structural integrity in a sample of 125 generally healthy older adults aged 43–87 years. Whole-brain voxelwise analysis, controlling for age and gender, revealed low density lipoprotein levels (LDL) as the most robust correlate of regional WM structural integrity of the measured lipids. Higher LDL was associated with decreased WM integrity in right frontal and temporal regions, the superior longitudinal fasciculus and internal/external capsules. Increasing LDL was associated with increased radial and axial diffusivity; however, more widespread statistical effects were found for radial diffusivity. These findings suggest that normal interindividual variation in lipid levels is associated with compromised regional WM integrity, even in individuals below clinical thresholds for hyperlipidemia. Given the prevalence of cholesterol-associated sequelae in older adults, and mounting evidence suggesting a vascular role in the etiology of dementia, the current data suggest that understanding the relationship between cholesterol and brain tissue microstructure may have important clinical implications for early detection of vascular-related cognitive disorders and optimal regulation of serum lipids to maintain neural health in older adults.
http://onlinelibrary.wiley.com/doi/10.1 ... 0/abstractObviously, fats are important to brain health and integrity, but this needs to be looked at in terms of endothelial health and blood flow from the heart to the brain, too. The brain does not exist in a vaccum. Too much LDL increasing cholesterol (which comes from saturated fats/animal fats/transfats) can contribute to blood vessel blockage and hypoperfusion. HDL is one way to balance that--good fats include coconut oil, olive oil, nuts, avocados) Here's some more info on how to raise HDL and decrease LDL with diet and lifestyle modifications.
http://heartdisease.about.com/cs/choles ... iseHDL.htmHere's an excellent write up on the need for good quality fats and the history of human brain development.
http://www.fi.edu/learn/brain/fats.htmland if people can get their LDL and HDL levels into the healthy zone, without statins, so much better for their livers! But this isn't possible for everyone... all things in balance and moderation,
cheer
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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS 
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