J Neurol Neurosurg Psychiatry 1988;51:260-265 doi:10.1136/jnnp.51.2.260
Perivascular iron deposition and other vascular damage in multiple sclerosis.
C W Adams
Division of Histopathology, United Medical School of Guy's Hospital, University of London, UK.
Evidence of damage to cerebral vein walls was sought in 70 cases of multiple sclerosis. Seventy control cases were also examined. The multiple sclerosis cases showed venous intramural fibrinoid deposition (7%), recent haemorrhages (17%), old haemorrhages revealed by haemosiderin deposition (30%), thrombosis (6%) and thickened veins (19%). In all, 41% of all multiple sclerosis cases showed some evidence of vein damage. Occasional control cases showed haemosiderin deposition in the brain but, unlike the multiple sclerosis cases, these were diffuse and almost entirely related to coexistent cardiovascular or cerebrovascular disease. Haemosiderin deposition was common in the substantia nigra and other pigmented nuclei in all cases. It is concluded that the cerebral vein wall in multiple sclerosis is subject to chronic inflammatory damage, which promotes haemorrhage and increased permeability, and constitutes a form of vasculitis.
They knew our cerebral veins were a mess and they failed to look further for a reason...
But I bring this up for the sake of considering why patients improve or don't improve after CCSVI treatment. What if the 41% who have vein damage in their brain itself, perhaps as a result of years of impaired flow and reflux, would have less relief of symptoms than the 59% who have no evidence of vein damage in their brain itself? The 41% vein damage/59% no vein damage is an echo of the ratio of 33%no improvements/66% improvements ratio we hear in CCSVI. I don't know that this is a big factor or that the ratio is anything more than a coincidence but, as always, there is research needed.
Remember that hemosiderin deposits would remain even if no more hemosiderin (blood iron) was deposited due to successful CCSVI treatment. There is some research supporting green tea as a natural chelator of hemosiderin. I don't drink as much as I should, especially considering that I enjoy green tea.