Cool! Genmati has published more iron gene research.
Ferroportin the iron exporter (FPN......) , known as Ferroportin disease, Hemochromatosis type 4. Well it really does make sense, and ties in with some of my personal theories, which in Ferroportins case (and tying in some other MS clues) goes something like this:
Firstly, iron is hidden away from invading pathogens. So you get infected with XXXX and iron is
hidden in places in the body, brain, organs to make it unavailable to the invader (just about everything needs iron to survive, including pathogens, cancers etc). Your bodies natural response when invaded is to hide iron. If Ferroportin (the iron exporter) is not functioning properly, the iron cannot be removed. It builds up, toxic, oxidises etc.
with Ferroportin gene, unlike classic hemochromatosis genes, you only need one gene to be effected, ie: a heterozygote. But I don't think that phlebotomy is going to help if the bodys iron exporter is faulty, you would just probably end up anemic.
Following on from some comments above, the way to check for iron overload is not serum iron, it's ferritin and also very importantly transferrin saturation, both would usually be high. In Ferroportin disease the transferrin saturation would be LOW. So quite different tests/results expected than being mentioned by some on this thread. Iron metabolism is incredibly complex, it's the next frontier, as big as bacteria some say.
Still phlebing every 3 months and feeling great. My sister has had some done and feels better for it, but can't find a method/person she is happy with for doing the venesections. But we are both classic hemochromatosis genes C282Y (H63d is more associated with MS funnily enough and is more common than C282Y)