New study challenges controversial MS treatment
- fiddler
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New study challenges controversial MS treatment
Interesting... a meta-study soon to come out soon will say that there are no studies that have been appropriately undertaken that can attest to the efficacy or otherwise of CCSVI treatment for MS symptoms.... yet this neurologist KNOWS that this one study (which may or may not have been appropriately done) absolutely PROVES that the treatment is useless: http://www.theglobeandmail.com/life/hea ... le4490423/. What a scientist! And here I am, 27 months into my placebo effect... I think we should wait for some real, valid research before we pass judgement.
Dx SPMS in 2004. Liberated 29/04/2010.
My blog: www.my-darn-ms.blogspot.com
My blog: www.my-darn-ms.blogspot.com
Re: New study challenges controversial MS treatment
i always notice the tone / wording of negative articles odd.
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Re: New study challenges controversial MS treatment
Four months of placebo effect here, and getting stronger.
tilt
tilt
...and I for one, welcome our new Neurologist overlords!
My before and after CCSVI treatment video http://www.youtube.com/watch?v=RhosV4_DvWw
Visit my Lego Amusement Rides website http://www.brickshelf.com/cgi-bin/gallery.cgi?m=Bolliger
My before and after CCSVI treatment video http://www.youtube.com/watch?v=RhosV4_DvWw
Visit my Lego Amusement Rides website http://www.brickshelf.com/cgi-bin/gallery.cgi?m=Bolliger
Re: New study challenges controversial MS treatment
geez“The debate in the scientific community was brief, swift and is over,” said David Hafler, chairman of the neurology department at the Yale School of Medicine. “The government has squandered precious resources not using peer-review, but instead using emotion and theologic belief and I think shame on the Canadian government for bowing into those pressures.”
let's look for intraluminal abnormalities with tools that can actually see intraluminal abnormalities: ultrasound, intravascular ultrasound, flouroscopy, autopsy
MRI has its value but is imperfect
and the study appears to have again confirmed the association (more CCSVI is present in MS patients than in healthy controls)
- cheerleader
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Re: New study challenges controversial MS treatment
The Globe and Mail has a particular slant, I'd say....
and the study also showed that CCSVI was linked to slowed blood flow through the brain.
That's kind of a big deal....hypoperfusion is not good for brain health.
cheer
and the study also showed that CCSVI was linked to slowed blood flow through the brain.
http://www.diagnosticimaging.com/mri/co ... 19/2098013Thirty-nine patients with MS and 26 healthy controls participated in the study. The patients with MS had tested positive for CCSVI by CDU.
The researchers found that the CCSVI-positive patients did show decreased blood flow and volume compared with the controls.
That's kind of a big deal....hypoperfusion is not good for brain health.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
- cheerleader
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Re: New study challenges controversial MS treatment
milesap--David's wife Sarah posts on This Is MS as Anecdote---you can find lots of info in the antibiotic thread. Jeff did the NAC test and was negative. http://www.davidwheldon.co.uk/NAC.html
Marie Rhodes did the Wheldon protocol for a while, but didn't help. Certainly a worthwhile avenue for those who restenose or do not benefit from venoplasty.
cheer
Marie Rhodes did the Wheldon protocol for a while, but didn't help. Certainly a worthwhile avenue for those who restenose or do not benefit from venoplasty.
cheer
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
Re: New study challenges controversial MS treatment
How does one distinguish between NAC's normal mucus thinning effect and a positive test for CPN (or is this even an issue)?cheerleader wrote:milesap--David's wife Sarah posts on This Is MS as Anecdote---you can find lots of info in the antibiotic thread. Jeff did the NAC test and was negative. http://www.davidwheldon.co.uk/NAC.html
Re: New study challenges controversial MS treatment
Another question... Wouldn't other thiol containing antioxidants, such as r-lipoic acid, be expected to have a similar effect on CPN?NHE wrote:How does one distinguish between NAC's normal mucus thinning effect and a positive test for CPN (or is this even an issue)?cheerleader wrote:milesap--David's wife Sarah posts on This Is MS as Anecdote---you can find lots of info in the antibiotic thread. Jeff did the NAC test and was negative. http://www.davidwheldon.co.uk/NAC.html
Re: New study challenges controversial MS treatment
“The debate in the scientific community was brief, swift and is over,”
Sounds like the academic version of premature ejaculation. Properly designed research takes a bit longer. Perhaps someone should tell Hafler to calm down and take it slowly. Strange thing is it is always us they blame for getting over-excited!
Sounds like the academic version of premature ejaculation. Properly designed research takes a bit longer. Perhaps someone should tell Hafler to calm down and take it slowly. Strange thing is it is always us they blame for getting over-excited!
- 1eye
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Re: New study challenges controversial MS treatment
What was it, brief or swift? No debate here any more... it's all done. I'm convinced.“The debate in the scientific community was brief, swift and is over,”
Premature academulation. Love it.
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Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
Not a doctor.
"I'm still here, how 'bout that? I may have lost my lunchbox, but I'm still here." John Cowan Hartford (December 30, 1937 – June 4, 2001)
Re: New study challenges controversial MS treatment
http://www.jvir.org/article/S1051-0443% ... 7/abstract
Purpose
This study proposed to prospectively evaluate safety and clinical changes in outpatient endovascular treatment in patients with multiple sclerosis (MS) and chronic cerebrospinal venous insufficiency (CCSVI).
Materials and Methods
Two hundred fifty-nine patients with MS were followed with the Multiple Sclerosis Impact Scale (MSIS-29) before and for 1and 6 months after treatment of extracranial internal jugular vein and azygos vein stenoses and occlusions using venous angioplasty, as well as stent placement in 2.5% of patients. Before treatment, the patients were tested with magnetic resonance (MR) venography and flow quantification.
Results
We found statistically significant improvements in the MSIS-29 scores (P < .01) at both 1 and 6 months. At 1 and 6 months, 67.9% and 53.6% were improved on the physical scale, respectively, and 53.0% and 44.4% were improved on the psychological scale, respectively. Women showed greater improvement than did men on the physical scale at 6 months (P = .01). Patients with primary progressive MS (PPMS) showed less improvement than did those with relapsing-remitting MS (RRMS) on the psychological scale at 1 month, and venoplasty treatment of more vein sites versus fewer vein sites showed greater improvement on the physical scale at both 1 and 6 months. Fifteen patients (6.3%) reported recurrent symptoms after clinical improvement and were treated again. There was one serious adverse event, a deep venous thrombosis at the catheter insertion site, which resolved with treatment.
Conclusions
Endovascular treatment of CCSVI in patients with MS appears to be a safe procedure resulting in significant clinical improvement.
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Re: New study challenges controversial MS treatment
NHE asked:
Of course, if someone has very bad congestion in their lungs, MAC is often used for thinning the mucus, but I guess most people know if they have this or not.
Also, hay fever sufferers like me are probably better off not trying it in the hay fever season!
As far as I know, other thiol containing antioxidants don't work this way: I don't know why.
Sarah
I don't think that one can say that the NAC test is a positive test for C pn but simply that it is a lot more accurate than many lab tests. For instance, it is reliant on having elementary bodies which react by having their di-sulphide bonds broken. If at the particular time one only has reticular or cryptic bodies, this won't happen. Now, some people seem not to respond but the react very strongly to antibiotics: this is probbly because the reaction to NAC was only very subtle because of the lack of elementary bodies.milesap--David's wife Sarah posts on This Is MS as Anecdote---you can find lots of info in the antibiotic thread. Jeff did the NAC test and was negative. http://www.davidwheldon.co.uk/NAC.html
How does one distinguish between NAC's normal mucus thinning effect and a positive test for CPN (or is this even an issue)?
Of course, if someone has very bad congestion in their lungs, MAC is often used for thinning the mucus, but I guess most people know if they have this or not.
Also, hay fever sufferers like me are probably better off not trying it in the hay fever season!
As far as I know, other thiol containing antioxidants don't work this way: I don't know why.
Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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