In 1979, Marshall was appointed as a Registrar in Medicine at the Royal Perth Hospital. He met Robin Warren, a pathologist interested in gastritis, during internal medicine fellowship training at Royal Perth Hospital in 1981. Together, the pair studied the presence of spiral bacteria in association with gastritis. In 1982, they performed the initial culture of H. pylori and developed their hypothesis related to the bacterial cause of peptic ulcer and gastric cancer. It has been claimed that the H. pylori theory was ridiculed by the establishment scientists and doctors, who did not believe that any bacteria could live in the acidic environment of the stomach. Marshall has been quoted as saying in 1998 that "(e)veryone was against me, but I knew I was right." On the other hand, it has also been argued that medical researchers showed a proper degree of scientific skepticism until the H. pylori hypothesis could be supported by evidence. German researchers had published several studies during the early 20th century, positing that bacterial infection was the principal cause of stomach ulcers, but they failed to attract wider interest or demonstrate an acceptable proof.
After failed attempts to infect piglets in 1984, Marshall, after having a baseline endoscopy done, drank a Petri dish containing cultured H. pylori, expecting to develop, perhaps years later, an ulcer. He was surprised when, only three days later, he developed vague nausea and halitosis, (due to the achlorhydria, there was no acid to kill bacteria in the stomach, and their waste products manifested as bad breath), noticed only by his mother. On days 5–8, he developed achlorydric (no acid) vomiting. On day eight, he had a repeat endoscopy and biopsy, which showed massive inflammation (gastritis), and H. Pylori was cultured. On the fourteenth day after ingestion, a third endoscopy was done, and Marshall began to take antibiotics. This story is related by Barry Marshall himself in his Nobel acceptance lecture Dec. 8, 2005, available for viewing on the Nobel website. Interestingly, Marshall did not develop antibodies to H. pylori, suggesting that innate immunity can sometimes eradicate acute H. pylori infection. Marshall's illness and recovery, based on a culture of organisms extracted from a patient, fulfilled Koch's postulates for H. pylori and gastritis, but not for peptic ulcer. This experiment was published in 1985 in the Medical Journal of Australia, and is among the most cited articles from the journal.
MarkW wrote:I wish you highly intelligent and well read people would stop using the term 'cause of MS'.
JCB wrote:Watching and reading some of the available documents, I have a question for this group. I have had multiple CCSVI procedures, my left IJV continues to want to occlude. Could this be caused by Cpn? Am I waisting my time to try and keep my vein open, because the Cpn is just causing inflamation there?
1eye wrote: If we can define it more accurately, point out "factors" that may exacerbate it, we can have a better idea how to avoid its problems and damage, making our lives fuller and less problematic.
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