brains drainage system discovered

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

brains drainage system discovered

Postby blossom » Tue Sep 11, 2012 7:13 pm

don't hear too much about the lymph. here is i think more bullets. if the lymph system is screwed up --------------???


http://techie-buzz.com/science/brain-dr ... ystem.html
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Re: brains drainage system discovered

Postby dania » Wed Sep 12, 2012 9:58 am

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Re: brains drainage system discovered

Postby Rogan » Wed Sep 12, 2012 7:39 pm

Thank you for this wonderful news.

And thank you to the NIH and the U.S. Department of Defense, and the Harold and Leila Y. Mathers Charitable Foundation for funding the University of Rochester to discover the glymphatic system.

What I have learned by reading Marie Rhodes book "CCSVI as the Cause of Multiple Sclerosis" is that understanding the "disease process" is the key to finding a proper treatment.

It looks like Parkinson's and Alzheimer’s diseases involve degenerative brain cells that are left as Lewy Bodies and amyloid plaques respectively. It sounds like the imaging used by Dr. Haacke to understand the hemodymanics in pwMS can't resolve this fine of a detail in a living person. Apparently Parkinson's and Alzheimer's involves even finer microcellular degeneration.

Thank you to our researchers for continuing their never ending process of understanding our bodies. If we were all practical people we would celebrate the failures as much as the success as illustrated in this above link. So if you are a failing researcher out there thank you from Rogan, please continue with your efforts. Or if you are the NIH please keep funding these people.

I think the future understanding of the issues put forward in this paper may help folks with Alzheimer's. Great news indeed.
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Re: brains drainage system discovered

Postby 1eye » Thu Sep 13, 2012 5:13 am

According to the simplified diagram in this video, drainage follows the veins. Is it possible the malformations of CCSVI are causing improper drainage alongside veins? There must be something equivalent to vein walls, if this drainage is to be confined to that space.

I just had a look at my pictures from my procedure in August 2010. Before ballooning, the dye went everywhere throughout a complex network of collateral veins, and they seemed to be formed haphazardly, often at right angles to what should be the direction of flow.

Will a complex network of malformed venous drainage confound the glymphatic system which is operating alongside it, physically in parallel to it?

If the network becomes more complex and/or disordered over time, will it eventually break the CSF/glymphatic drainage system in an increasingly worse manner?
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Re: brains drainage system discovered

Postby 1eye » Thu Sep 13, 2012 5:18 am

Will a jugular bypass help or hinder the glymphatic/CSF drainage?
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Re: brains drainage system discovered

Postby 1eye » Thu Sep 13, 2012 5:21 am

Will ballooning disrupt this drainage?
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Re: brains drainage system discovered

Postby 1eye » Thu Sep 13, 2012 5:45 am

Is the glymphatic/CSF system involved in restenosis? In particular, does the ballooning result in damage to this system, the response to which makes veins even more narrowed than they were before the ballooning?
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Re: brains drainage system discovered

Postby blossom » Thu Sep 13, 2012 9:03 pm

glymphatic and lymphatic even though their job is the same "clean up" i don't think they are quite the same.

In most of the body, a network of vessels carry lymph, a fluid that removes excess plasma, dead blood cells, debris and other waste. But the brain is different. Instead of lymph, the brain is bathed in cerebrospinal fluid. For decades, however, neuroscientists have assumed that this fluid simply carries soluble waste by slowly diffusing through tissues, then shipping its cargo out of the nervous system and eventually into the body’s bloodstream. Determining what’s really going on has been impossible until recently.

here is a link about the lymph and immune-notice the many lymph vessels-also as 1eye said they could be impacting the veins and arteries. it sure is important but you don't hear much on it. but if it's not working right it screws with pretty much everything.

www.innerbody.com/image/lympov.html
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Re: brains drainage system discovered

Postby ThisIsMA » Sat Sep 15, 2012 11:50 am

People with MS (myself included) often are found to have "slowed perfusion" as one finding of their MRI.

I've had brain MRI's at two facilities since being diagnosed. At one facility I was found to have slowed perfusion, at the other facility perfusion wasn't mentioned as a finding of my MRI.

My take on that is not that I didn't have slowed perfusion during the other MRI, but that they probably didn't look at my brain perfusion at all.

At any rate, isn't the "means of perfusion" what they're talking about in the video Dania posted and in the first article posted to this thread? If so, that seems extremely relevent to MS and to CCSVI.

It makes sense to me that if the CSF ends up at the veins after it travels through the brain, then vein stenosis could negatively impact cerebro-spinal fluid (CSF) flow.

What I wasn't sure about from the video posted to this thread was I couldn't tell if the CSF ends up at the veins and then enters the veins to be discharged from the brain through the veins? Or if it continues to travel out of the brain parellel to but outside of the veins? Their description of this in the video wasn't clear (at least not to me with my cog fog brain).

Also since MS brain lesions tend to be "periventricular" meaning parellel to and nearby the veins, it seems like the fact that they've now discovered that CSF is transported parellel to the veins implicates issues with CSF as a possible cause of MS lesions, since the CSF transport structures are just outside the veins (in the vicinity of the MS brain lesions).
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Re: brains drainage system discovered

Postby PointsNorth » Sat Sep 15, 2012 12:55 pm

Could we therefore expect there to be reflux of CSF and glymphatic system breach of the BxBB?

*** my spellcheck keeps inserting 'lymphatic'. Steep part of the curve on it's way. Or it could be moving so fast that by the time it reaches us that we miss it altogether :-)
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